DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33639 and gpr139

DIOPT Version :9

Sequence 1:	NP_001027070.1	Gene:	CG33639 / 32803	FlyBaseID:	FBgn0053639	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001352082.1	Gene:	gpr139 / 798482	ZFINID:	ZDB-GENE-050823-2	Length:	363	Species:	Danio rerio

Alignment Length:	440	Identity:	96/440 - (21%)
Similarity:	164/440 - (37%)	Gaps:	161/440 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VLAANATSVFSSDLRDDFYRDVEDPRTESLREYCYGLVLPIICAMGIIGNVLNLVVLTRRNMR-- 91
            ||..|::|              ..||...|.::.......::| :|:..|:|.:::|::..:|
Zfish     9 VLTTNSSS--------------WSPRGCPLGQFPVVYYSSLLC-LGLPANILTVIILSQLVLRRQ 58

  Fly    92 GTAYIYMRAYSTA---ALLAIVFA------------IPFGIRMLVHKDRGQWEEFGPAFYTAHLE 141
            .::|.|:.|.:.|   .||.|||.            :|..:...|     |..||.    :.|..
Zfish    59 KSSYNYLLALAVADILVLLLIVFVDFLLEDFILGAPLPHSLNKAV-----QVLEFS----SIHTS 114

  Fly   142 LYLGNGCLGVGVMMLLVLTIERYVSVCHPGFARPVMGPPG-----VVVFLTCLATVIVYL--PSI 199
            :::           .:.|||:||::||||.....|..|..     :.|:..||.:.:.|.  |.:
Zfish   115 IWI-----------TVPLTIDRYIAVCHPLRYHTVSYPARTRKVILAVYAGCLISSVPYYWWPEL 168

  Fly   200 FRGELIKCILGSSD------------VYVYLRRDNTIYQQTIFYRVYKIMLEVIFKLVPTLVIGG 252
            :.|     :.|:|.            |:|:..   |:|                  |:|..|...
Zfish   169 WHG-----LPGASPGGRSSSAGQHVLVWVHCA---TVY------------------LLPCSVFFS 207

  Fly   253 LNMRIM--MVYRRTCERRRKMVLSRPHAQGHGHGHGHGHGHGHGHAHGHGYLKDDDPRKFAEERR 315
            ||..|:  :..||:|.|.|                        |::.|               :.
Zfish   208 LNAIIVRKLRCRRSCFRLR------------------------GYSTG---------------KT 233

  Fly   316 LFLLLGSTSILFLVCVSPMAILHMTIASEVYPSFP-----FQVFRASANLLELINYSLTFYIYCL 375
            ..:||..||: |.|..:|..::.:.....|.|:.|     ..:....||:|.|:|..:.|::||.
Zfish   234 TAILLAITSV-FAVLWAPRTLMILYHLYTVQPAMPGPARLLHLVTDVANMLALLNTGVNFFLYCF 297

  Fly   376 FSEDFRNTLVRTIKWPWLKGKF-CHQ------AEH--EVSASP---PATA 413
            .|:.||. :..|:    ||..| |.:      |.|  .:::||   ||.:
Zfish   298 ISKRFRR-MAGTV----LKAFFRCRKQPPPFYASHNFSITSSPWISPANS 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33639	NP_001027070.1	7tm_1	77..>278	CDD:278431	53/238 (22%)
gpr139	NP_001352082.1	7tmA_GPR139	28..306	CDD:320585	78/365 (21%)
		TM helix 1	28..53	CDD:320585	5/25 (20%)
		TM helix 2	61..86	CDD:320585	9/24 (38%)
		TM helix 3	100..130	CDD:320585	10/49 (20%)
		TM helix 4	142..162	CDD:320585	3/19 (16%)
		TM helix 5	186..211	CDD:320585	9/45 (20%)
		TM helix 6	228..260	CDD:320585	8/47 (17%)
		TM helix 7	274..299	CDD:320585	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840