Protein Alignment CG33639 and GPR139

DIOPT Version :10

• Sequence 1: NP_001027070.1
• Gene: CG33639 / 32803
• FlyBaseID: FBgn0053639
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001002911.1
• Gene: GPR139 / 124274
• HGNCID: 19995
• Length: 353
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 72/354 - (20%)
• Similarity: 131/354 - (37%)
• Gaps: 112/354 - (31%)

  Fly    63 YGLVLPIICAMGIIGNVLNLVVLTR--RNMRGTAYIYMRAYSTAALLAIVFAIPFGIRMLVHKDR 125
            |.|:|    .:|:..|:|.:::|::  ...:.::|.|:.|.:.|.:|.:.|.:
Human    33 YSLLL----CLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIV------------ 81

  Fly   126 GQWEEFGPAFYTAHLELYLGN----------------GCLGVGVMMLLVLTIERYVSVCHPGFAR 174
                     |....||.::.|                ..:...:.:.:.|||:||::||||....
Human    82 ---------FVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYH 137

  Fly   175 PVMGPPG-----VVVFLTCLATVIVYL--PSIFRGELIKCILGSSDVYVYLRRDNTIYQQTIFYR 232
            .|..|..     |.|::||..|.|.|.  |:|:..:.|...:....::::.            :.
Human   138 TVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHC------------FT 190

  Fly   233 VYKIMLEVIFKLVPTLVIGGLNMRIMMVYRRTCERRRKMVLSRPHAQGHGHGHGHGHGHGHGHAH 297
            ||         |||..:...||..|:...||....|.:                       |::.
Human   191 VY---------LVPCSIFFILNSIIVYKLRRKSNFRLR-----------------------GYST 223

  Fly   298 GHGYLKDDDPRKFAEERRLFLLLGSTSILFLVCVSP--MAILHMTIASEVYPSFPFQVFRASANL 360
            |               :...:|...||| |....:|  :.||:....:.:...:...:....||:
Human   224 G---------------KTTAILFTITSI-FATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANM 272

  Fly   361 LELINYSLTFYIYCLFSEDFRNTLVRTIK 389
            |.|:|.::.|::||..|:.||.....|:|
Human   273 LALLNTAINFFLYCFISKRFRTMAAATLK 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33639	NP_001027070.1	7tmA_FMRFamide_R-like	61..384	CDD:410630	70/347 (20%)
		TM helix 1	62..88	CDD:410630	7/26 (27%)
		TM helix 2	94..119	CDD:410630	6/24 (25%)
		TM helix 3	138..168	CDD:410630	8/45 (18%)
		TM helix 4	178..198	CDD:410630	8/26 (31%)
		TM helix 5	231..256	CDD:410630	7/24 (29%)
		TM helix 6	311..339	CDD:410630	8/29 (28%)
		TM helix 7	352..377	CDD:410630	8/24 (33%)
GPR139	NP_001002911.1	7tmA_GPR139	27..296	CDD:320585	70/347 (20%)
		TM helix 1	28..54	CDD:320585	7/24 (29%)
		TM helix 2	62..87	CDD:320585	7/45 (16%)
		TM helix 3	101..131	CDD:320585	5/29 (17%)
		TM helix 4	143..163	CDD:320585	6/19 (32%)
		TM helix 5	180..205	CDD:320585	7/45 (16%)
		TM helix 6	221..253	CDD:320585	9/47 (19%)
		TM helix 7	264..289	CDD:320585	8/24 (33%)