DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33639 and GPR139

DIOPT Version :9

Sequence 1:NP_001027070.1 Gene:CG33639 / 32803 FlyBaseID:FBgn0053639 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_001002911.1 Gene:GPR139 / 124274 HGNCID:19995 Length:353 Species:Homo sapiens


Alignment Length:354 Identity:72/354 - (20%)
Similarity:131/354 - (37%) Gaps:112/354 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 YGLVLPIICAMGIIGNVLNLVVLTR--RNMRGTAYIYMRAYSTAALLAIVFAIPFGIRMLVHKDR 125
            |.|:|    .:|:..|:|.:::|::  ...:.::|.|:.|.:.|.:|.:.|.:            
Human    33 YSLLL----CLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIV------------ 81

  Fly   126 GQWEEFGPAFYTAHLELYLGN----------------GCLGVGVMMLLVLTIERYVSVCHPGFAR 174
                     |....||.::.|                ..:...:.:.:.|||:||::||||....
Human    82 ---------FVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYH 137

  Fly   175 PVMGPPG-----VVVFLTCLATVIVYL--PSIFRGELIKCILGSSDVYVYLRRDNTIYQQTIFYR 232
            .|..|..     |.|::||..|.|.|.  |:|:..:.|...:....::::.            :.
Human   138 TVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHC------------FT 190

  Fly   233 VYKIMLEVIFKLVPTLVIGGLNMRIMMVYRRTCERRRKMVLSRPHAQGHGHGHGHGHGHGHGHAH 297
            ||         |||..:...||..|:...||....|.:                       |::.
Human   191 VY---------LVPCSIFFILNSIIVYKLRRKSNFRLR-----------------------GYST 223

  Fly   298 GHGYLKDDDPRKFAEERRLFLLLGSTSILFLVCVSP--MAILHMTIASEVYPSFPFQVFRASANL 360
            |               :...:|...||| |....:|  :.||:....:.:...:...:....||:
Human   224 G---------------KTTAILFTITSI-FATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANM 272

  Fly   361 LELINYSLTFYIYCLFSEDFRNTLVRTIK 389
            |.|:|.::.|::||..|:.||.....|:|
Human   273 LALLNTAINFFLYCFISKRFRTMAAATLK 301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33639NP_001027070.1 7tm_1 77..>278 CDD:278431 45/225 (20%)
GPR139NP_001002911.1 7tmA_GPR139 27..296 CDD:320585 70/347 (20%)
TM helix 1 29..53 CDD:320585 7/23 (30%)
TM helix 2 63..85 CDD:320585 7/42 (17%)
TM helix 3 102..124 CDD:320585 1/21 (5%)
TM helix 4 147..163 CDD:320585 6/15 (40%)
TM helix 5 181..204 CDD:320585 6/43 (14%)
TM helix 6 227..249 CDD:320585 6/22 (27%)
TM helix 7 264..289 CDD:320585 8/24 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157870
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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