DRSC - DRSC Integrative Ortholog Prediction Tool

DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hesr and BHLHE40

DIOPT Version :10

Sequence 1:	NP_525094.1	Gene:	Hesr / 32800	FlyBaseID:	FBgn0030899	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_003661.1	Gene:	BHLHE40 / 8553	HGNCID:	1046	Length:	412	Species:	Homo sapiens

Alignment Length:	19	Identity:	7/19 - (36%)
Similarity:	12/19 - (63%)	Gaps:	0/19 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 ASVHIALPKLSAREDFKQI 315
            |::|:.||.|..|..|:.:
Human   155 AALHLPLPVLLGRLTFQPV 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	bHLH_SF	16..77	CDD:469605
Hesr	NP_525094.1	Hairy_orange	101..>116	CDD:470640
BHLHE40	NP_003661.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer	1..139
		bHLH-O_DEC1	40..129	CDD:381592
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269\|PubMed:19786558	75..79
		ORANGE	140..184	CDD:128787	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..303
Blue background indicates that the domain is not in the aligned region.

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