DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hesr and Bhlhe40

DIOPT Version :9

Sequence 1:NP_525094.1 Gene:Hesr / 32800 FlyBaseID:FBgn0030899 Length:149 Species:Drosophila melanogaster
Sequence 2:NP_445780.2 Gene:Bhlhe40 / 79431 RGDID:68439 Length:411 Species:Rattus norvegicus


Alignment Length:141 Identity:42/141 - (29%)
Similarity:66/141 - (46%) Gaps:18/141 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KSHVGAKSRSHQYREVFK---PMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGDVLEL 70
            ||..|.| ||...:|.:|   .::|:|||.|||.|:..:||||.|  ||...|:..::...||||
  Rat    38 KSRRGIK-RSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPE--HLKLTTLGHLEKAVVLEL 99

  Fly    71 AVHHLSKKNCPV---ATPTTAPTSGVYQSPI---------DCYWSGFRECVLEVSQFLQHNGYQP 123
            .:.|:......:   .....|..||:....:         :.:.|||:.|..||.|:|..:....
  Rat   100 TLKHVKALTNLIDQQQQKIMALQSGLQAGDLSGRNIEAGQEMFCSGFQTCAREVLQYLAKHENTR 164

  Fly   124 SFEFAKELDHL 134
            ..:.::.:.||
  Rat   165 DLKSSQLVTHL 175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HesrNP_525094.1 HLH 21..77 CDD:238036 23/58 (40%)
Hairy_orange 101..>116 CDD:295407 7/14 (50%)
Bhlhe40NP_445780.2 Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250 1..139 32/103 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
bHLH-O_DEC1 40..129 CDD:381592 30/91 (33%)
Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250 75..79 2/3 (67%)
ORANGE 140..184 CDD:128787 10/36 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..293
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334609
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.840

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