DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hesr and hey1

DIOPT Version :9

Sequence 1:	NP_525094.1	Gene:	Hesr / 32800	FlyBaseID:	FBgn0030899	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_997726.1	Gene:	hey1 / 58008	ZFINID:	ZDB-GENE-000607-70	Length:	317	Species:	Danio rerio

Alignment Length:	159	Identity:	39/159 - (24%)
Similarity:	66/159 - (41%)	Gaps:	34/159 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SHVGAKSRSH----QYREVFKPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGDVLEL 70
            |.:|:.|.|.    |.|:..:.::|::||.|||..|..::.|:.......|.  ||::..::|::
Zfish    33 SPLGSMSPSTTSQVQARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQM 95

  Fly    71 AVHHLSKKNCPVATPTTAPTSGVYQS---PIDCYWSGFRECVLEVSQFL---------------- 116
            .|.||...:       .|...|.:.:   .:|....|||||:.|.:::|
Zfish    96 TVDHLKMLH-------AAGGKGYFDAHALAMDYRGLGFRECLAETARYLSIIEGLDNTDPLRIRL 153

  Fly   117 -QH-NGYQPSFEFAKELDHLVASTSKSKP 143
             .| |.|....|....|.||...::...|
Zfish   154 VSHLNSYASQREAHSGLGHLAWGSAFGTP 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	HLH	21..77	CDD:238036	16/55 (29%)
Hesr	NP_525094.1	Hairy_orange	101..>116	CDD:295407	6/14 (43%)
hey1	NP_997726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		7/25 (28%)
		HLH	49..106	CDD:238036	16/65 (25%)
		ORANGE	119..165	CDD:128787	11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..264
		YRPW motif	307..310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740