DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hesr and Heyl

DIOPT Version :9

Sequence 1:	NP_525094.1	Gene:	Hesr / 32800	FlyBaseID:	FBgn0030899	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_038933.2	Gene:	Heyl / 56198	MGIID:	1860511	Length:	326	Species:	Mus musculus

Alignment Length:	167	Identity:	43/167 - (25%)
Similarity:	72/167 - (43%)	Gaps:	37/167 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MARPEEQKSHVGAKSRSHQYREVFKPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGD 66
            ||||....|     ....|.|:..:.::|::||.|||..|..::.|:.......|.  :|::..:
Mouse    29 MARPLTTPS-----PSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAE 86

  Fly    67 VLELAVHHLSKKNCPVATPTTAPTSGVYQS---PIDCYWSGFRECVLEVSQFLQHNGY--QPSFE 126
            ||::.|.||...:....|       |.:.:   .:|....|||||:.||.::|   |.  .||..
Mouse    87 VLQMTVDHLKMLHASGGT-------GFFDARALAVDFRSIGFRECLTEVIRYL---GVLEGPSSH 141

  Fly   127 F----AKELDHLVASTSKSKPN----------LWRPW 149
            .    .:.|.||.:..::.:|:          :| ||
Mouse   142 ADPVRIRLLSHLKSYAAEMEPSPTTTSALAFPVW-PW 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	HLH	21..77	CDD:238036	16/55 (29%)
Hesr	NP_525094.1	Hairy_orange	101..>116	CDD:295407	7/14 (50%)
Heyl	NP_038933.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		8/31 (26%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		19/77 (25%)
		HLH	44..100	CDD:238036	16/57 (28%)
		ORANGE	115..162	CDD:128787	15/49 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..260
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740