DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hesr and HES6

DIOPT Version :9

Sequence 1:	NP_525094.1	Gene:	Hesr / 32800	FlyBaseID:	FBgn0030899	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_061115.2	Gene:	HES6 / 55502	HGNCID:	18254	Length:	224	Species:	Homo sapiens

Alignment Length:	116	Identity:	32/116 - (27%)
Similarity:	55/116 - (47%)	Gaps:	9/116 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 REVFKPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGDVLELAVHHLSKKNCPVATPT 86
            |:..||::|:|||:|||..|..::.||     ...|..||::..:||||.|..:.    .|....
Human    26 RKARKPLVEKKRRARINESLQELRLLL-----AGAEVQAKLENAEVLELTVRRVQ----GVLRGR 81

  Fly    87 TAPTSGVYQSPIDCYWSGFRECVLEVSQFLQHNGYQPSFEFAKELDHLVAS 137
            ......:.....:.:.:|:.:|:.||..|:.......:...|:.|:||:.|
Human    82 AREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLES 132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	HLH	21..77	CDD:238036	21/54 (39%)
Hesr	NP_525094.1	Hairy_orange	101..>116	CDD:295407	4/14 (29%)
HES6	NP_061115.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		1/4 (25%)
		HLH	23..75	CDD:238036	21/53 (40%)
		Hairy_orange	96..134	CDD:311465	10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..205
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700