Protein Alignment Hesr and HES2

DIOPT Version :10

• Sequence 1: NP_525094.1
• Gene: Hesr / 32800
• FlyBaseID: FBgn0030899
• Length: 149
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 171
• Identity: 42/171 - (24%)
• Similarity: 71/171 - (41%)
• Gaps: 50/171 - (29%)

  Fly    20 QYREVFKPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGDVLELAVHHLSKKNCPVAT 84
            :.|:..||::|::||:|||:.|..:|.|:..:...:....:|::..||||:.|..|  :..|.::
Human    12 ELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFL--QELPASS 74

  Fly    85 -PTTAPTSGVYQSPIDCYWSGFRECVLEVSQFLQH-NGYQPSFEFAKELDHLVASTSKSK----- 142
             ||.||.      |.|.|..|:..||..:::.|.. ...:|:.. |:.|:||....:.:.
Human    75 WPTAAPL------PCDSYREGYSACVARLARVLPACRVLEPAVS-ARLLEHLWRRAASATLDGGR 132

  Fly   143 ----------------------------------PNLWRPW 149
                                              |.|||||
Human   133 AGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	bHLH_SF	16..77	CDD:469605	19/56 (34%)
		Hairy_orange	101..>116	CDD:470640	4/14 (29%)
HES2	NP_061962.2	bHLH-O_HES2	10..74	CDD:381469	20/63 (32%)
		ORANGE	84..127	CDD:128787	11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		4/44 (9%)
		WRPW motif	170..173		2/2 (100%)