Protein Alignment Hesr and HEYL

DIOPT Version :10

• Sequence 1: NP_525094.1
• Gene: Hesr / 32800
• FlyBaseID: FBgn0030899
• Length: 149
• Species: Drosophila melanogaster
• Sequence 2: NP_055386.2
• Gene: HEYL / 26508
• HGNCID: 4882
• Length: 328
• Species: Homo sapiens
• Alignment Length: 167
• Identity: 44/167 - (26%)
• Similarity: 72/167 - (43%)
• Gaps: 37/167 - (22%)

  Fly     2 MARPEEQKSHVGAKSRSHQYREVFKPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGD 66
            ||||....|     |...|.|:..:.::|::||.|||..|..::.|:.......|.  :|::..:
Human    29 MARPLSTPS-----SSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAE 86

  Fly    67 VLELAVHHLSKKNCPVATPTTAPTSGVYQS---PIDCYWSGFRECVLEVSQFLQHNGY--QPSFE 126
            ||::.|.||...:....|       |.:.:   .:|....|||||:.||.::|   |.  .||..
Human    87 VLQMTVDHLKMLHATGGT-------GFFDARALAVDFRSIGFRECLTEVIRYL---GVLEGPSSR 141

  Fly   127 F----AKELDHLVASTSKSKPN----------LWRPW 149
            .    .:.|.||.:..::.:|:          .| ||
Human   142 ADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAW-PW 177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	bHLH_SF	16..77	CDD:469605	18/60 (30%)
		Hairy_orange	101..>116	CDD:470640	7/14 (50%)
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		10/32 (31%)
		bHLH-O_HEYL	36..109	CDD:381453	21/86 (24%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		19/77 (25%)
		ORANGE	115..162	CDD:128787	15/49 (31%)
		PHA03247	<136..311	CDD:223021	9/43 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..308