DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hesr and HEYL

DIOPT Version :9

Sequence 1:NP_525094.1 Gene:Hesr / 32800 FlyBaseID:FBgn0030899 Length:149 Species:Drosophila melanogaster
Sequence 2:NP_055386.2 Gene:HEYL / 26508 HGNCID:4882 Length:328 Species:Homo sapiens


Alignment Length:167 Identity:44/167 - (26%)
Similarity:72/167 - (43%) Gaps:37/167 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MARPEEQKSHVGAKSRSHQYREVFKPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGD 66
            ||||....|     |...|.|:..:.::|::||.|||..|..::.|:.......|.  :|::..:
Human    29 MARPLSTPS-----SSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAE 86

  Fly    67 VLELAVHHLSKKNCPVATPTTAPTSGVYQS---PIDCYWSGFRECVLEVSQFLQHNGY--QPSFE 126
            ||::.|.||...:....|       |.:.:   .:|....|||||:.||.::|   |.  .||..
Human    87 VLQMTVDHLKMLHATGGT-------GFFDARALAVDFRSIGFRECLTEVIRYL---GVLEGPSSR 141

  Fly   127 F----AKELDHLVASTSKSKPN----------LWRPW 149
            .    .:.|.||.:..::.:|:          .| ||
Human   142 ADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAW-PW 177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HesrNP_525094.1 HLH 21..77 CDD:238036 16/55 (29%)
Hairy_orange 101..>116 CDD:295407 7/14 (50%)
HEYLNP_055386.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 10/32 (31%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 19/77 (25%)
HLH 42..100 CDD:238036 17/59 (29%)
ORANGE 115..162 CDD:128787 15/49 (31%)
Atrophin-1 <136..311 CDD:331285 9/43 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..308
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140922
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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