DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hesr and HEY1

DIOPT Version :9

Sequence 1:	NP_525094.1	Gene:	Hesr / 32800	FlyBaseID:	FBgn0030899	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	NP_001035798.1	Gene:	HEY1 / 23462	HGNCID:	4880	Length:	308	Species:	Homo sapiens

Alignment Length:	96	Identity:	28/96 - (29%)
Similarity:	51/96 - (53%)	Gaps:	16/96 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MMERKRRSRINRCLDFIKDLLQEVSHLDGETM----AKMDMGDVLELAVHHLSKKNCPVATPTTA 88
            ::|::||.|||..|..::.|:.  |..:.:.|    ||::..::|::.|.||...:       ||
Human    56 IIEKRRRDRINNSLSELRRLVP--SAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH-------TA 111

  Fly    89 PTSGVYQS---PIDCYWSGFRECVLEVSQFL 116
            ...|.:.:   .:|....|||||:.||:::|
Human   112 GGKGYFDAHALAMDYRSLGFRECLAEVARYL 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hesr	NP_525094.1	HLH	21..77	CDD:238036	16/52 (31%)
Hesr	NP_525094.1	Hairy_orange	101..>116	CDD:295407	7/14 (50%)
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		bHLH_SF	41..126	CDD:381792	19/78 (24%)
		ORANGE	124..170	CDD:128787	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..238
		YRPW motif	298..301
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740