Protein Alignment HES1 and E(spl)m8-HLH

DIOPT Version :9

• Sequence 1: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Sequence 2: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Alignment Length: 245
• Identity: 50/245 - (20%)
• Similarity: 88/245 - (35%)
• Gaps: 75/245 - (30%)

Human    34 HRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTA 98
            ::|..||::|::||||:|:.|..||||:.:....|..  .:::||::||..|..:|. |:.....
  Fly    10 YQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGI--LRMDKAEMLESAVIFMRQ-QKTPKKV 71

Human    99 ALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPAL 163
            |.......|..::.|:...:|||:|.:::..|::.::...::.||......:.      |.|.|.
  Fly    72 AQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQ------QFHEAQ 130

Human   164 QAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQ 228
            .|
  Fly   131 SA--------------------------------------------------------------- 132

Human   229 FAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPW 278
             |..|.|.....|....|:..::||  ...:..||:..|......:||||
  Fly   133 -ADFIQNSMDCSSMDKAPLSPASSG--YHSDCDSPAPSPQPMQQPLWRPW 179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		3/9 (33%)
		bHLH-O_HES1_4	33..95	CDD:381465	22/60 (37%)
		Hairy_orange	110..148	CDD:400076	8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		4/42 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		7/25 (28%)
		WRPW motif	275..278		2/2 (100%)
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	22/59 (37%)
		ORANGE	81..125	CDD:128787	8/49 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840