DRSC/TRiP Functional Genomics Resources

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Protein Alignment HES1 and E(spl)m5-HLH

DIOPT Version :9

Sequence 1:NP_005515.1 Gene:HES1 / 3280 HGNCID:5192 Length:280 Species:Homo sapiens
Sequence 2:NP_524511.1 Gene:E(spl)m5-HLH / 43158 FlyBaseID:FBgn0002631 Length:178 Species:Drosophila melanogaster


Alignment Length:261 Identity:53/261 - (20%)
Similarity:97/261 - (37%) Gaps:85/261 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    18 PASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILE 82
            |.|.|:|....|| ..:.|..||::|::||||:|:.|..||||:.:....|:.  .:::||::||
  Fly     3 PQSNNSTTFVSKT-QHYLKVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAI--LRMDKAEMLE 64

Human    83 MTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCM 147
            ..:..:|. |..:..|.:|  |..:..::.|:...::|::|.::....::.:|...::.||.   
  Fly    65 AALVFMRK-QVVKQQAPVS--PLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLG--- 123

Human   148 TQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEA 212
            .:...|....|...::....|.|..|                                       
  Fly   124 VEFQRMLQADQVQTSVTTSTPRPLSP--------------------------------------- 149

Human   213 AKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRP 277
                                      |.||     |.|::..|      ..::.|....::||||
  Fly   150 --------------------------ASSG-----YHSDNEDS------QSAASPKPVEETMWRP 177

Human   278 W 278
            |
  Fly   178 W 178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HES1NP_005515.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 9/25 (36%)
bHLH-O_HES1_4 33..95 CDD:381465 21/61 (34%)
Hairy_orange 110..148 CDD:400076 6/37 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 157..200 4/42 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..280 7/25 (28%)
WRPW motif 275..278 2/2 (100%)
E(spl)m5-HLHNP_524511.1 HLH 20..72 CDD:238036 19/53 (36%)
ORANGE 87..131 CDD:128787 7/46 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140910
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000785
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.840

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