Protein Alignment HES1 and E(spl)m3-HLH

DIOPT Version :10

• Sequence 1: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Sequence 2: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 266
• Identity: 70/266 - (26%)
• Similarity: 110/266 - (41%)
• Gaps: 71/266 - (26%)

Human    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNL-QRAQM 96
            ::||..||::|::||||||:.|..||.|:::.|:::....::||||||||:||.|:|.| ||..:
  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74

Human    97 ----------TAALSTDPSVLGKYRAGFSECMNEVTRFL---STCEGVNTEVRTRLLGHLANCMT 148
                      :...||..:.:..:|:|:....:::|:.|   ...:.:..::...|...|....|
  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQT 139

Human   149 QINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGG--AAPPPGGAPCKLGSQAGE 211
            |:.......|.|...|                       :|...|  |.|..||    .|..|..
  Fly   140 QLLQQQQQQQQHQQQQ-----------------------IPQSSGRLAFPLLGG----YGPAAAA 177

Human   212 AAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSP----SSGPSLTAD 272
            ||..:..|                  ......:|.|      |||..||:|.    ||..|..::
  Fly   178 AAISYSSF------------------LTSKDELIDV------TSVDGNALSETASVSSQESGASE 218

Human   273 SMWRPW 278
            .:||||
  Fly   219 PVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	31/62 (50%)
		Hairy_orange	109..148	CDD:462193	6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		13/29 (45%)
		WRPW motif	275..278		2/2 (100%)
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	29/60 (48%)
		ORANGE	96..136	CDD:128787	6/39 (15%)