Protein Alignment HES1 and E(spl)mbeta-HLH

DIOPT Version :10

• Sequence 1: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Sequence 2: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Alignment Length: 257
• Identity: 72/257 - (28%)
• Similarity: 114/257 - (44%)
• Gaps: 84/257 - (32%)

Human    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97
            ::||..||::|::||||||:.|.:||.::::.|.::....::||||||||:||:|::.| |||..
  Fly    12 QYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKL-RAQKQ 75

Human    98 AALST---------DP--SVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQIN 151
            ..||:         ||  |:...:|||:....|||::.|:...||:.::.|:|:.||.:.:..:.
  Fly    76 LRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQ 140

Human   152 AMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVF 216
            .:.      |:|..        |.|..||       |.......|||  :.|.
  Fly   141 VVV------PSLPI--------GVPLQAP-------VEDQAMVTPPP--SECD------------ 170

Human   217 GGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPW 278
                           .:.:||                .|..|:..|.:|||      |||||
  Fly   171 ---------------SLESGA----------------CSPAPSEASSTSGP------MWRPW 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	28/61 (46%)
		Hairy_orange	109..148	CDD:462193	13/38 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		11/25 (44%)
		WRPW motif	275..278		2/2 (100%)
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	30/63 (48%)
		ORANGE	97..141	CDD:128787	13/43 (30%)