DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HES1 and h

DIOPT Version :9

Sequence 1:NP_005515.1 Gene:HES1 / 3280 HGNCID:5192 Length:280 Species:Homo sapiens
Sequence 2:NP_001014577.1 Gene:h / 38995 FlyBaseID:FBgn0001168 Length:337 Species:Drosophila melanogaster


Alignment Length:309 Identity:107/309 - (34%)
Similarity:147/309 - (47%) Gaps:80/309 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    15 AATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKAD 79
            |..||.:..||.|     ..|:|:|||||||||||||..|::||||||||.|||.:|||||||||
  Fly    17 AVVPAQLKETPLK-----SDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKAD 76

Human    80 ILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLA 144
            |||.|||||:.|||.|.....:.||.::.|::|||::|:|||:||    .|:....|.|||.||:
  Fly    77 ILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQRRRLLQHLS 137

Human   145 NCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQA 209
            ||:..:....:..|.....|:           .||...|.||..|              :..||.
  Fly   138 NCINGVKTELHQQQRQQQQQS-----------IHAQMLPSPPSSP--------------EQDSQQ 177

Human   210 GEAAK-VFG------------GFQVVPA--PDGQFAFLIPN------------------------ 235
            |.||. :||            |.||:|.  |:|..|.::|.                        
  Fly   178 GAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAVAA 242

Human   236 ----GAFAHSGPVI---PVYTSNSGTSVGPNAVSPSSGPSLTADSMWRP 277
                .|.|...|::   |..|:::|::...::....|.|..::...:.|
  Fly   243 AAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAP 291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HES1NP_005515.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 12/28 (43%)
bHLH-O_HES1_4 33..95 CDD:381465 47/61 (77%)
Hairy_orange 110..148 CDD:400076 18/37 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 157..200 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..280 3/24 (13%)
WRPW motif 275..278 1/3 (33%)
hNP_001014577.1 HLH 29..88 CDD:238036 45/63 (71%)
ORANGE 106..141 CDD:128787 19/38 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 92 1.000 Domainoid score I7601
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 155 1.000 Inparanoid score I4315
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1427802at2759
OrthoFinder 1 1.000 - - FOG0000785
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105205
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3450
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.870

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