DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Frq2 and GUCA1C

DIOPT Version :9

Sequence 1:	NP_001259675.1	Gene:	Frq2 / 32799	FlyBaseID:	FBgn0083228	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_005450.3	Gene:	GUCA1C / 9626	HGNCID:	4680	Length:	209	Species:	Homo sapiens

Alignment Length:	156	Identity:	48/156 - (30%)
Similarity:	87/156 - (55%)	Gaps:	5/156 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KEIRQWHKGFLKDCPNGLLTEQGFIKIYKQFFPDGDPSKFASLVFRVFDENNDGAIEFEEFIRAL 89
            :|...|::.|:.:.|:||.|...|..:......:...:|....|:..||.|.||.::|.|||.|:
Human    17 QETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAV 81

  Fly    90 SITSRGNLDEKLHWAFRLYDVDNDGYITREEMYNIVDAIYQMVGQQPQTEDENTPQKRVDKIFDQ 154
            ::..:..:::||.|.|:|||.|.:|.|.:.|:.::..|:..:.|||..     :|::.::.:|.:
Human    82 NLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNGQQTL-----SPEEFINLVFHK 141

  Fly   155 MDKNHDDRLTLEEFREGSKADPRIVQ 180
            :|.|:|..||||||..|...|..:::
Human   142 IDINNDGELTLEEFINGMAKDQDLLE 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frq2	NP_001259675.1	FRQ1	9..178	CDD:227455	48/152 (32%)
GUCA1C	NP_005450.3	FRQ1	15..165	CDD:227455	48/152 (32%)
		EFh	56..118	CDD:238008	22/61 (36%)
		EFh	92..160	CDD:238008	27/72 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810