DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Frq2 and RCVRN

DIOPT Version :9

Sequence 1:	NP_001259675.1	Gene:	Frq2 / 32799	FlyBaseID:	FBgn0083228	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_002894.1	Gene:	RCVRN / 5957	HGNCID:	9937	Length:	200	Species:	Homo sapiens

Alignment Length:	188	Identity:	83/188 - (44%)
Similarity:	126/188 - (67%)	Gaps:	8/188 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG-KKNSKLKQDTIDRLTTDTYFTEKEIRQWHKGFLKDCPNGLLTEQGFIKIYKQFFPDGDPSKF 64
            || .|:..|.::.::.|..:|.|:|:|:..|::.||||||.|.:|:|.|..||.:||||.||..:
Human     1 MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAY 65

  Fly    65 ASLVFRVFDENNDGAIEFEEFIRALSITSRGNLDEKLHWAFRLYDVDNDGYITREEMYNIVDAIY 129
            |..|||.||.|.||.::|:|::.||.:|:.|..::||.|||.|||||.:|.|::.|:..||.||:
Human    66 AQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIF 130

  Fly   130 QMVGQQPQ-----TEDENTPQKRVDKIFDQMDKNHDDRLTLEEFREGSKADPRIVQAL 182
            :|:  .|:     .:|||||:||.:||:....||.||:||.:||.||:.|:..|::.:
Human   131 KMI--TPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLI 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frq2	NP_001259675.1	FRQ1	9..178	CDD:227455	78/173 (45%)
RCVRN	NP_002894.1	FRQ1	14..182	CDD:227455	78/169 (46%)
RCVRN	NP_002894.1	Interaction with GRK1. /evidence=ECO:0000250\|UniProtKB:P21457	189..192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495747at33208
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820