DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Frq2 and KCNIP3

DIOPT Version :9

Sequence 1:	NP_001259675.1	Gene:	Frq2 / 32799	FlyBaseID:	FBgn0083228	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_038462.1	Gene:	KCNIP3 / 30818	HGNCID:	15523	Length:	256	Species:	Homo sapiens

Alignment Length:	189	Identity:	80/189 - (42%)
Similarity:	120/189 - (63%)	Gaps:	10/189 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NSKLKQDTI-------DRLTTDTYFTEKEIRQWHKGFLKDCPNGLLTEQGFIKIYKQFFPDGDPS 62
            :|:|:..|:       |:|...|.||:||::..::||..:||.||:.|..|..||.||||.||.:
Human    64 DSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDAT 128

  Fly    63 KFASLVFRVFDENNDGAIEFEEFIRALSITSRGNLDEKLHWAFRLYDVDNDGYITREEMYNIVDA 127
            .:|..:|..||.:.:|||.||:|:..|||..||.:.|||.|||.|||::.|||||:|||..|:.:
Human   129 TYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKS 193

  Fly   128 IYQMVGQQ--PQTEDENTPQKRVDKIFDQMDKNHDDRLTLEEFREGSKADPRIVQALSL 184
            ||.|:|:.  |... |:.|.:.|::.|::||:|.|..:|:|||.|..:.|..|:.::.|
Human   194 IYDMMGRHTYPILR-EDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQL 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frq2	NP_001259675.1	FRQ1	9..178	CDD:227455	76/177 (43%)
KCNIP3	NP_038462.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		FRQ1	81..245	CDD:227455	74/164 (45%)
		EFh	130..192	CDD:238008	33/61 (54%)
		EFh	166..238	CDD:238008	34/72 (47%)
		Interaction with KCND2. /evidence=ECO:0000250	243..256		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810