DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Frq1 and NCS1

DIOPT Version :9

Sequence 1:	NP_001033853.1	Gene:	Frq1 / 32797	FlyBaseID:	FBgn0030897	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_055101.2	Gene:	NCS1 / 23413	HGNCID:	3953	Length:	190	Species:	Homo sapiens

Alignment Length:	188	Identity:	134/188 - (71%)
Similarity:	157/188 - (83%)	Gaps:	1/188 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKKSSKLKQDTIDRLTTDTYFTEKEIRQWHKGFLKDCPNGLLTEQGFIKIYKQFFPQGDPSKFA 65
            |||.:||||.:.::.||..|||||||::||:|||:||||:|.|...||.||||||||.|||:|||
Human     1 MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFA 65

  Fly    66 SLVFRVFDENNDGSIEFEEFIRALSVTSKGNLDEKLQWAFRLYDVDNDGYITREEMYNIVDAIYQ 130
            :.||.|||||.||.|||.|||:||||||:|.|||||:|||:|||:||||||||.||.:|||||||
Human    66 TFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQ 130

  Fly   131 MVGQQPQ-SEDENTPQKRVDKIFDQMDKNHDGKLTLEEFREGSKADPRIVQALSLGGG 187
            |||...: .|:||||:||||:||..||||.||||||:||:|||||||.|||||||..|
Human   131 MVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDG 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frq1	NP_001033853.1	FRQ1	9..178	CDD:227455	120/169 (71%)
NCS1	NP_055101.2	FRQ1	20..179	CDD:227455	117/158 (74%)
NCS1	NP_055101.2	Interaction with IL1RAPL1. /evidence=ECO:0000269\|PubMed:12783849	174..190		12/15 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6079
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5719
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2944
Isobase	1	0.950	-	0	Normalized mean entropy	S161
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1369072at2759
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	1	1.000	-	-		otm40850
orthoMCL	1	0.900	-	-		OOG6_100764
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R801
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810