DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-1 and ARI3

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_189408.1	Gene:	ARI3 / 822393	AraportID:	AT3G27710	Length:	537	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	177/537 - (32%)
Similarity:	258/537 - (48%)	Gaps:	79/537 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDN---DNDFCDNVDSGNVSSGDDGDDDFG-MEVDL-PSSADRQMDQDDYQYKVLTTDEIVQH 60
            ||.|.   |:|:.:..|. |.|.    ||::. .|||| |.::.:...|      |:..:.:|..
plant     1 MDDDYMMLDDDYGEEEDE-NYSE----DDNYSEAEVDLQPVTSTKSTSQ------VIKKESLVAA 54

  Fly    61 QREIIDEANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKT 125
            |:||:.....||.:.....|.||.:::|:.|||...:.|...|..|.||. :..|..:....:||
plant    55 QKEILVRVMELLSVKENQARTLLIYYQWNVEKLFSVFADQGKDRMFSCAG-LTVFVPSLVTSKKT 118

  Fly   126 SRSQCEECEICF-SQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDD 189
            .:     |::|. ..||.:.|..:|||||||..||..:.:.|| .||..:.|.|.||.|..:.|:
plant   119 MK-----CDVCMEDDLPSNVMTRMECGHRFCNDCWIGHFTVKI-NEGESKRILCMAHECKAICDE 177

  Fly   190 VTVANLVTDARVRVKYQQLITNSFVECNQLLRWCPS-VDCTYAV-KVPYA-EPRRVHCKCGHVFC 251
            ..|..||: ..:..:|.:.:..|:||.|.:::|||| ..|..|: |:... :...|.|.||..||
plant   178 DVVRKLVS-PELADRYDRFLIESYVEDNNMVKWCPSKPHCGSAIRKIEDGHDVVEVGCSCGLQFC 241

  Fly   252 FACGENWHDPVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKN 316
            |:|....|.|..|...|.|.|||:|:|||.|||..|||.||:||..|:|..|||.|.||   |..
plant   242 FSCLSESHSPCSCLMWKLWKKKCEDESETVNWITVNTKLCPKCSKPIQKRDGCNLMTCK---CGQ 303

  Fly   317 EFCWVC---LGSWEPHGS-SWYNCNRYDEDEAKTARDAQEKLRSSLARYLHYYNRYMNHMQSMKF 377
            .|||:|   .|....:.| :.::|.||.:::.:....||.    .|.||.||:.||..|:.|:|.
plant   304 HFCWLCGQATGRDHTYTSIAGHSCGRYKDEKVRQLERAQR----DLDRYTHYHYRYKAHIDSLKL 364

  Fly   378 ENKLYASVKQK----MEEMQQ---HNMSWIEVQFLKKAVDILCQCRQTLMYTYVFAYY------- 428
            |:||..|:.:|    .|...|   ...||:     ..||:.|...|:.|..:|.||:|
plant   365 EDKLRKSILEKAVSNSETKDQKVFKEYSWV-----TDAVNRLFISRRILSQSYPFAFYMFGEELF 424

  Fly   429 ----------LKKNNQSMIFEDNQKDLESATEMLSEYLERDITSENLADIKQKVQDKYRYCEKRC 483
                      :|||    :|||.|:.||...|.||:.||......:    .:||.:..|:.....
plant   425 KDEMSEKEREIKKN----LFEDQQQQLEGNVEKLSKILEEPFDEYD----HEKVVEMMRHLTNLT 481

  Fly   484 SV---LLKHVHEGYDKE 497
            :|   |.|.::|..:.|
plant   482 AVVDNLCKEMYECIENE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	22/62 (35%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	21/42 (50%)
ARI3	NP_189408.1	RING-HC_RBR_TRIAD1_like	121..171	CDD:319537	22/50 (44%)
		RING-HC finger (C3HC4-type)	121..171	CDD:319537	22/50 (44%)
		IBR	190..254	CDD:214763	22/63 (35%)
		IBR	<277..311	CDD:366672	20/36 (56%)
		COG4026	<431..519	CDD:226513	22/76 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2944
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I974
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1176
orthoMCL	1	0.900	-	-		OOG6_100963
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830