DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-1 and ankib1b

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_009290458.1	Gene:	ankib1b / 561277	ZFINID:	ZDB-GENE-100920-6	Length:	1074	Species:	Danio rerio

Alignment Length:	515	Identity:	156/515 - (30%)
Similarity:	236/515 - (45%)	Gaps:	95/515 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GMEVDLPSSADRQMDQDDYQYKVLTTDEI-----VQHQREIID----EANLLLKLPTPTTRILLN 84
            |:|..:..|.|...:..:.:|..|...|.     ||..|.:.|    |...:|:.|..|...||.
Zfish   197 GLESQMVFSTDPNAEDIEAEYAALDRREFYEGLRVQDLRRLKDMLIVETADMLQAPLFTAEALLR 261

  Fly    85 HFKWDKEKLLEKYFDDNTDEFFKCAHVINP------FNATEAIKQ----KTSRSQCEE------- 132
            ...||:|||||.:. .|.::..:.:.|..|      :|..:.:..    :|:||....
Zfish   262 AHDWDREKLLEAWM-SNAEDCCQRSGVQMPIPPPRGYNTWDTLPSPRTPRTTRSSITSPDEISLT 325

  Fly   133 --------CEICFS-----QLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCD 184
                    |.||..     :.|.|    :.|||.||..||..:|:.|| .||....|.|.|:.|.
Zfish   326 PADDDHSLCGICMCAASMFEEPVD----IPCGHEFCRGCWESFLNLKI-QEGEAHNIFCPAYDCF 385

  Fly   185 ILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKV-----------PYAE 238
            .|| .|.|...:....:..:|.|....:|||.|..:||||...|..||::           |.:.
Zfish   386 QLV-PVEVIESIVSKEMDKRYLQFDIKAFVENNPAIRWCPRAGCDRAVRLAGQGPGASTSDPLSF 449

  Fly   239 PR----RVHCKCGHVFCFACGENWHDPVKCRWLKKWIKKCDD--------------DSETSNWIA 285
            ||    .|.|..||:||:.|....|:|..|:..|.|::|..|              |:....|:.
Zfish   450 PRLQAPAVDCGKGHLFCWECQGEAHEPCDCQTWKMWLQKVTDMKPEELAGVSEAYEDAANCLWLL 514

  Fly   286 ANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVCLGSWEPHGSS---WYNCNRYD-----ED 342
            .|:|.|..|...|:|:.|||||.|  ..||.:|||:||..|:.|.||   :|.|.||:     |:
Zfish   515 TNSKSCANCKSPIQKNEGCNHMQC--AKCKYDFCWICLEEWKKHSSSTGGYYRCTRYEVIQQVEE 577

  Fly   343 EAKTAR-DAQEKLRS--SLARYLHYYNRYMNHMQSMKFENKLYASVKQKMEEMQQHNMSWIE--- 401
            ::|... :|::|.::  .|.|::|||.|:.||..|.:.|.:|..:.|.|||::.: .:|..|
Zfish   578 QSKEMTVEAEKKHKNFQELDRFMHYYTRFKNHEHSYQLEERLLKTAKDKMEQLSK-VLSGREGGP 641

  Fly   402 --VQFLKKAVDILCQCRQTLMYTYVFAYYLK-KNNQSMIFEDNQKDLESATEMLSEYLER 458
              ..|::.||..|.:.|:.|..:|.:.::|: |:.:..|||..|.|||..||.|::.:.|
Zfish   642 PDTTFIEDAVHELLKTRRILKCSYPYGFFLEPKSTKKEIFELMQTDLEMVTEDLAQKVNR 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	25/74 (34%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	19/39 (49%)
ankib1b	XP_009290458.1	ANK	47..195	CDD:238125
		ANK repeat	47..77	CDD:293786
		Ank_2	50..176	CDD:289560
		ANK repeat	79..143	CDD:293786
		ANK repeat	145..176	CDD:293786
		RING	334..380	CDD:302633	18/50 (36%)
		IBR	403..476	CDD:279784	24/72 (33%)
		IBR	502..553	CDD:279784	21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920