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Protein Alignment ari-1 and ANKIB1

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_061877.1	Gene:	ANKIB1 / 54467	HGNCID:	22215	Length:	1089	Species:	Homo sapiens

Alignment Length:	542	Identity:	152/542 - (28%)
Similarity:	247/542 - (45%)	Gaps:	100/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSDNDNDFCDNVDSGNVSSGDDGDDDFGMEVDLPSSADRQMDQDDYQYKVLTTDEIVQHQRE--- 63
            :::|.:..||..:..:     ..|....:|..:..|.|.:.::.:.:|..|...|..:..|.
Human   174 ENENKDTPCDCAEKQH-----HKDLALNLESQMVFSRDPEAEEIEAEYAALDKREPYEGLRPQDL 233

  Fly    64 -------IIDEANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINP------F 115
                   |::.|: :|:.|..|...||....||:|||||.:. .|.:...:.:.|..|      :
Human   234 RRLKDMLIVETAD-MLQAPLFTAEALLRAHDWDREKLLEAWM-SNPENCCQRSGVQMPTPPPSGY 296

  Fly   116 NATEAIKQ----KTSRSQCEE---------------CEICFSQL-----PPDSMAGLECGHRFCM 156
            ||.:.:..    :|:||....               |:||...:     |.|    :.|||.||.
Human   297 NAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPVD----MPCGHDFCR 357

  Fly   157 PCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLR 221
            .||..:|:.|| .||....|.|.|:.|..|| .|.:...|....:..:|.|....:|||.|..::
Human   358 GCWESFLNLKI-QEGEAHNIFCPAYDCFQLV-PVDIIESVVSKEMDKRYLQFDIKAFVENNPAIK 420

  Fly   222 WCPSVDCTYAVKV---------------PYAEPRRVHCKCGHVFCFACGENWHDPVKCRWLKKWI 271
            |||:..|..||::               |......|.|..||:||:.|....|:|..|:..|.|:
Human   421 WCPTPGCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQTWKNWL 485

  Fly   272 KKCD--------------DDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVC 322
            :|..              :|:....|:..|:|.|..|...|:|:.|||||.|  ..||.:|||:|
Human   486 QKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQC--AKCKYDFCWIC 548

  Fly   323 LGSWEPHGSS---WYNCNRYD-----EDEAKTAR-DAQEKLR--SSLARYLHYYNRYMNHMQSMK 376
            |..|:.|.||   :|.|.||:     |:::|... :|::|.:  ..|.|::|||.|:.||..|.:
Human   549 LEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRFKNHEHSYQ 613

  Fly   377 FENKLYASVKQKMEE----MQQHNMSWIEVQFLKKAVDILCQCRQTLMYTYVFAYYLK-KNNQSM 436
            .|.:|..:.|:|||:    :::......:..|::.||.:|.:.|:.|..:|.:.::|: |:.:..
Human   614 LEQRLLKTAKEKMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKE 678

  Fly   437 IFEDNQKDLESATEMLSEYLER 458
            |||..|.|||..||.|::.:.|
Human   679 IFELMQTDLEMVTEDLAQKVNR 700

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.