DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-1 and Rnf19a

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_038951.1	Gene:	Rnf19a / 30945	MGIID:	1353623	Length:	840	Species:	Mus musculus

Alignment Length:	213	Identity:	64/213 - (30%)
Similarity:	97/213 - (45%)	Gaps:	31/213 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 ECEICFSQLP----PDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTV 192
            ||.:|..:..    ||.|.   |.||.|:.|..:||..:|....:  .|||..  |....:...:
Mouse   131 ECPLCLLRHSKDRFPDIMT---CHHRSCVDCLRQYLRIEISESRV--NISCPE--CTERFNPHDI 188

  Fly   193 ANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPY--AEPRRVHC---KCGHVFCF 252
            ..:::|..:..||::.:...::..:...||||:.||.||| :.:  |...::.|   .||..||:
Mouse   189 RLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAV-IAFGCASCPKLTCGREGCGTEFCY 252

  Fly   253 ACGENWHDPVKCRWLK---------KWIKKCD-DDSETSNWIAANTKECPRCSVTIEK--DGGCN 305
            .|.:.||....|...:         :.|:... ..|:.|...|.:.|.||||:..|.|  ||.||
Mouse   253 HCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCN 317

  Fly   306 HMVCKNQNCKNEFCWVCL 323
            ||.|....|  ||||:|:
Mouse   318 HMTCAVCGC--EFCWLCM 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	20/64 (31%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	20/40 (50%)
Rnf19a	NP_038951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	128..351		64/213 (30%)
		RING	132..179	CDD:214546	16/53 (30%)
		IBR	199..264	CDD:214763	20/65 (31%)
		IBR	<297..335	CDD:279784	20/39 (51%)
		AzlC	<361..450	CDD:294385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..685
		Interaction with CASR. /evidence=ECO:0000250	660..840
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..721
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810