DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-1 and Arih1

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001013126.2	Gene:	Arih1 / 300756	RGDID:	1308131	Length:	555	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	341/555 - (61%)
Similarity:	409/555 - (73%)	Gaps:	53/555 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSD-------NDNDFCDNVDSGNVSSGDDGDD-------DFG----MEVDLPSSADR------- 40
            ||||       ::::.|...|||.....||.:|       |.|    :|..|....:|
  Rat     1 MDSDEGYNYEFDEDEECSEEDSGAEEEEDDDEDEPDDDNLDLGEVELVEPGLGVGGERDGLLCGE 65

  Fly    41 -------------------------QMDQDDYQYKVLTTDEIVQHQREIIDEANLLLKLPTPTTR 80
                                     ...::||:|:|||.::|:||..|.|.|.|.:::.|...||
  Rat    66 TGGGGGSALGPGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITR 130

  Fly    81 ILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKTSRSQCEE--CEICFSQLPPD 143
            |||:||.||||||:|:|||.|.::.|...|||||...:.. :|..:||..::  |:||:...|..
  Rat   131 ILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRT-RQMNTRSSAQDMPCQICYLNYPNS 194

  Fly   144 SMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLVTDARVRVKYQQL 208
            ...||||||:|||.||.|||:|||:.||:||||||.||||||||||.||..|:||::|::|||.|
  Rat   195 YFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHL 259

  Fly   209 ITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHCKCGHVFCFACGENWHDPVKCRWLKKWIKK 273
            |||||||||:||:|||:.||.:.|||.|.:.:.|.||||..|||.|||||||||||:||||||||
  Rat   260 ITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKK 324

  Fly   274 CDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVCLGSWEPHGSSWYNCNR 338
            |||||||||||||||||||:|.||||||||||||||:|||||.||||||||.||||||:||||||
  Rat   325 CDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNR 389

  Fly   339 YDEDEAKTARDAQEKLRSSLARYLHYYNRYMNHMQSMKFENKLYASVKQKMEEMQQHNMSWIEVQ 403
            |:||:||.||||||:.|::|.|||.|.|||||||||::||:||||.|||||||||||||||||||
  Rat   390 YNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQ 454

  Fly   404 FLKKAVDILCQCRQTLMYTYVFAYYLKKNNQSMIFEDNQKDLESATEMLSEYLERDITSENLADI 468
            |||||||:|||||.|||||||||:||||||||:|||:||.|||:|||:||.||||||:.::|.||
  Rat   455 FLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDI 519

  Fly   469 KQKVQDKYRYCEKRCSVLLKHVHEGYDKEWWEYTE 503
            ||||||||||||.|..|||:||||||:|:.|||.|
  Rat   520 KQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIE 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	41/59 (69%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	35/39 (90%)
Arih1	NP_001013126.2	RING-HC_RBR_HHARI	183..240	CDD:319540	37/56 (66%)
		IBR	255..315	CDD:214763	41/59 (69%)
		IBR	<337..377	CDD:396187	35/39 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354091
Domainoid	1	1.000	297	1.000	Domainoid score	I1409
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111871
Inparanoid	1	1.050	727	1.000	Inparanoid score	I588
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		oto96194
orthoMCL	1	0.900	-	-		OOG6_100963
Panther	1	1.100	-	-	LDO	PTHR11685
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770