DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-1 and Rnf217

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001139821.1	Gene:	Rnf217 / 268291	MGIID:	3610311	Length:	515	Species:	Mus musculus

Alignment Length:	212	Identity:	57/212 - (26%)
Similarity:	88/212 - (41%)	Gaps:	44/212 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 CEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQT-ISCAAHGCDILVDDVTVA-NL 195
            |.:|....|...:..  |....|..|...|||:::   .|||. |.|....|...:::.||. ||
Mouse   236 CRVCLEDKPIKPLPC--CKKAVCEECLKIYLSSQV---QLGQVEIKCPVTECFEFLEETTVVYNL 295

  Fly   196 VTDARVRVKYQQLITNSFVECNQL---LRWCPSVDC----TYAVKVPYAEPRR------VHC-KC 246
            ..:..::.||       |:|..::   .:.||  .|    |:..|.....|.|      :.| .|
Mouse   296 THEDSIKYKY-------FLELGRIDSSTKPCP--QCKHFTTFKKKGHIPTPSRSESRYKIQCPTC 351

  Fly   247 GHVFCFACGENWHDPVKCRWLKKWIKKCDDDSETSNWIA------ANTKECPRCSVTIEKDGGCN 305
            ..::||.|...||:.|.|:..||      .|....:|.:      .|.::||:|.:.|::..||:
Mouse   352 QLIWCFKCHSPWHEGVNCKEYKK------GDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCD 410

  Fly   306 HMVCKNQNCKNEFCWVC 322
            ||.|  ..|...||:.|
Mouse   411 HMTC--SQCNTNFCYRC 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	19/73 (26%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	14/37 (38%)
Rnf217	NP_001139821.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..125
		Tankyrase_bdg_C	<62..131	CDD:291973
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..189
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	232..451		57/212 (27%)
		IBR	302..369	CDD:214763	19/75 (25%)
		IBR	<397..429	CDD:279784	12/31 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810