DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-1 and Rbck1

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001077390.1	Gene:	Rbck1 / 24105	MGIID:	1344372	Length:	508	Species:	Mus musculus

Alignment Length:	301	Identity:	65/301 - (21%)
Similarity:	87/301 - (28%)	Gaps:	149/301 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 EAIKQKTSRSQCE-----------------------ECEICFSQLPPDSMAGL-ECGHRFCMPCW 159
            ||::|...|.|.:                       ||.:|:|.|.|.....| ||.|.||..|
Mouse   243 EALRQYQQRKQQQQEGNYLQHVQLEQRSLVLNTEPTECPVCYSVLAPGEAVVLRECLHTFCREC- 306

  Fly   160 HEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLRWCP 224
                     .:|                   |:.| ..:|.|.                    ||
Mouse   307 ---------LQG-------------------TIRN-SQEAEVA--------------------CP 322

  Fly   225 SVDCTYA------------------------VKVPYAEPRRV---HCK----------------- 245
            .:|.||:                        :.|..||.|..   |||
Mouse   323 FIDSTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEF 387

  Fly   246 ----CGHVFCFACGENWHDPVKCRWLKKWIKKCDDD--SETSNWIAA-NTKE------------- 290
                |..|.|..| :..|:.:.||       :..||  ....|.:|| .|.|
Mouse   388 TCPVCTRVNCLLC-KAIHEHMNCR-------EYQDDLALRAQNDVAARQTTEMLKVMLQQGEAMH 444

  Fly   291 CPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVCLG-SWEPHG 330
            ||:|.:.::|..||:.:.|  ..|..|.|||..| .|.|.|
Mouse   445 CPQCRIVVQKKDGCDWIRC--TVCHTEICWVTKGPRWGPGG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	17/107 (16%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	16/54 (30%)
Rbck1	NP_001077390.1	Interaction with TAB2. /evidence=ECO:0000250\|UniProtKB:Q9BYM8	1..268		5/24 (21%)
		Interaction with IRF3. /evidence=ECO:0000250\|UniProtKB:Q9BYM8	1..218
		Hoil1_N	57..131	CDD:176394
		Interaction with RNF31. /evidence=ECO:0000250\|UniProtKB:Q9BYM8	69..131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..191
		ZnF_RBZ	195..215	CDD:197784
		RanBP2-type Zn finger	195..214	CDD:275376
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	276..504		60/268 (22%)
		zf-RING_UBOX	280..322	CDD:290181	17/91 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900