Protein Alignment ari-1 and Arih2

DIOPT Version :10

• Sequence 1: NP_523399.1
• Gene: ari-1 / 32796
• FlyBaseID: FBgn0017418
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_035920.1
• Gene: Arih2 / 23807
• MGIID: 1344361
• Length: 492
• Species: Mus musculus
• Alignment Length: 495
• Identity: 163/495 - (32%)
• Similarity: 270/495 - (54%)
• Gaps: 23/495 - (4%)

  Fly     5 NDNDFCDNVDSGNVSSGDDGD-DDF--GMEVDLPSSADRQMDQDDYQYKVLTTDEIVQHQREIID 66
            |:.|:..|.:.......|.|| :|:  |:..|:........|.::||:..||..|......|.:.
Mouse    13 NEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMT 77

  Fly    67 EANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKTSRSQCE 131
            ....:||:.....:::|.:|.|...::|::|..::.....:.....||      .|...:.....
Mouse    78 SLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNP------SKHVPTAHPPH 136

  Fly   132 ECEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLV 196
            .|.:|...:..:::..|.|.|:||..||.::.|. :|.:|:|..|||.|..|.:...:..|..|:
Mouse   137 HCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGISCMAQDCPLRTPEDFVFPLL 200

  Fly   197 TDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHC-KCGHVFCFACGENWHD 260
            .:..:|.||::.:...:||.:..|:.||..||...::|.....|||.| :|..||||.|.:.:|.
Mouse   201 PNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHA 265

  Fly   261 PVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVCLGS 325
            |..|..::||:.||.|||||:|:|:|:||:||:|::.|||:||||||.|  ..||::|||:|||.
Mouse   266 PTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGD 328

  Fly   326 WEPHGSSWYNCNRYDEDEAKTARDAQEKLRSSLARYLHYYNRYMNHMQSMKFENKLYASVKQKME 390
            |:.|||.:|.|:||.|:.....:..|.:.|.:|.:||.|:.|:.||.:|::.|.:.|..:.:|::
Mouse   329 WKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQ 393

  Fly   391 EMQQHNM-SWIEVQFLKKAVDILCQCRQTLMYTYVFAYYLKKNNQSMIFEDNQKDLESATEMLSE 454
            |...:|: :||:.|:|:.|..:|.:||.||.|||.:|||::...:..:||..|..||:..|.||.
Mouse   394 ERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSW 458

  Fly   455 YLERDITSENLADIKQK--VQDKYRYCEKRCSVLLKHVHE 492
            .:||       ||...:  ::::....|:|...|||..|:
Mouse   459 KVER-------ADSYDRGDLENQMHIAEQRRRTLLKDFHD 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_523399.1	RING-HC_RBR_HHARI	131..189	CDD:438288	18/57 (32%)
		BRcat_RBR_HHARI-like	198..279	CDD:439004	30/81 (37%)
		Rcat_RBR_HHARI-like	283..340	CDD:439017	32/56 (57%)
		Ariadne	341..>459	CDD:466073	41/118 (35%)
Arih2	NP_035920.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		6/23 (26%)
		UBA-like. /evidence=ECO:0000250|UniProtKB:Q9Y4X5	64..111		10/46 (22%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	134..343		86/211 (41%)
		RING-HC_RBR_TRIAD1	136..189	CDD:438429	18/53 (34%)
		BRcat_RBR_TRIAD1	216..287	CDD:439005	30/70 (43%)
		Rcat_RBR_TRIAD1	291..346	CDD:439021	33/56 (59%)
		Ariadne	351..>477	CDD:466073	43/132 (33%)
		Ariadne domain. /evidence=ECO:0000250|UniProtKB:Q9Y4X5	358..492		48/141 (34%)