DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-1 and ari-1.3

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001379539.1	Gene:	ari-1.3 / 172282	WormBaseID:	WBGene00016156	Length:	491	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	246/508 - (48%)
Similarity:	331/508 - (65%)	Gaps:	22/508 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDNDNDFCDNVDSGNVSSGDDGDDDFGMEVD----LPSSADRQMDQDDYQYKVLTTDEIVQHQ 61
            |:|| |..:.:    |:.||.||.||:...:.|    ...||...:::.|...:||..|.:....
Worm     1 MNSD-DEIYME----GSASSEDDMDDECLSDDDGIARHDQSASDYLNKKDKDNEVLDHDSLEAEM 60

  Fly    62 REIIDEANLLLKLPTPTTRILLNHFKWDKEKLLEKYFD-DNTDEFFKCAHVINPFNATEAIKQKT 125
            ::.|.|...:|::.|...||||:.:||:||.|||:::: .:|..|...|.||       ..:|:.
Worm    61 KKAISEVEAVLQVKTGVCRILLHKYKWNKESLLERFYEHPDTIAFLIDAQVI-------PRQQEV 118

  Fly   126 SRSQCEECEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDV 190
            ..:...||:||.|.   |.::||.|.||.|..||..||:.|||::...: |.|.|..|.:|::|.
Worm   119 IPAGDAECDICCSM---DELSGLSCNHRACAECWQAYLTNKIVSDAQSE-IECMAPNCKLLIEDE 179

  Fly   191 TVANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHCKCGHVFCFACG 255
            .|.:.::|..:..||::|:..|:||.|.||||||.:||..||||.:.|||.|.|.||..|||:||
Worm   180 KVLSYISDPTMVSKYRKLMVASYVEINCLLRWCPGIDCGKAVKVSHWEPRLVVCSCGTCFCFSCG 244

  Fly   256 ENWHDPVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCW 320
            :|||:|:.||.||||||||.|||||.|||.||||:||:|.:.|||:||||.|:|.|..|:.||||
Worm   245 QNWHEPLNCRHLKKWIKKCQDDSETMNWINANTKDCPKCMIPIEKNGGCNRMLCTNSGCRYEFCW 309

  Fly   321 VCLGSWEPHGSSWYNCNRYDEDEAKTARDAQEKLRSSLARYLHYYNRYMNHMQSMKFENKLYASV 385
            :||..|..||.. |.||.|||...|..:||||..|::|.|||.|:||||.|.||::.|.||...|
Worm   310 MCLEPWTKHGYQ-YACNGYDETAVKNPQDAQEISRANLKRYLFYFNRYMGHEQSLQLEGKLNIKV 373

  Fly   386 KQKMEEMQQHNMSWIEVQFLKKAVDILCQCRQTLMYTYVFAYYLKKNNQSMIFEDNQKDLESATE 450
            .:|||:|:..:|||||||||:||||||.:||:||||||.||:||||:|.|:|||.||.:||..||
Worm   374 AKKMEQMENMSMSWIEVQFLRKAVDILSECRRTLMYTYAFAFYLKKDNNSIIFESNQANLEMETE 438

  Fly   451 MLSEYLERDITSENLADIKQKVQDKYRYCEKRCSVLLKHVHEGYDKEWWEYTE 503
            .||.:||||:..|:|..:||||||||||.|:|..|||.|..||.:::.|:|.:
Worm   439 QLSGFLERDLEDEDLVTLKQKVQDKYRYVEQRRKVLLDHCAEGAEQDIWQYND 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	35/59 (59%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	24/39 (62%)
ari-1.3	NP_001379539.1	RING_Ubox	125..178	CDD:418438	24/56 (43%)
		RING-HC finger (C3HC4-type)	126..172	CDD:319361	21/49 (43%)
		IBR	193..253	CDD:214763	35/59 (59%)
		IBR	<274..315	CDD:396187	24/40 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167534
Domainoid	1	1.000	238	1.000	Domainoid score	I1280
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	535	1.000	Inparanoid score	I649
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm4735
orthoMCL	1	0.900	-	-		OOG6_100963
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810