DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-1 and RNF19B

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_699172.2	Gene:	RNF19B / 127544	HGNCID:	26886	Length:	732	Species:	Homo sapiens

Alignment Length:	228	Identity:	70/228 - (30%)
Similarity:	101/228 - (44%)	Gaps:	28/228 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 FNATEAIKQKTSRSQCEECEICFSQLPPDSMAG-LECGHRFCMPCWHEYLSTKIVAEGLGQTISC 178
            |:..||.:.....::..||.:|..:|||:.... |.|.||.|..|...||..:|....:  .|||
Human   101 FDDEEAAEGGGPGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRV--PISC 163

  Fly   179 AAHGCDILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPY--AEPRR 241
            ..  |...::...:..|:.|..:..||::.:...::..:...||||:.||.||| :.|  |...:
Human   164 PE--CSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAV-IAYGCASCPK 225

  Fly   242 VHCK---CGHVFCFACGENWHDPVKC-----------RWLKKWIKKCDDDSETSNWIAANTKECP 292
            :.|:   |...||:.|.:.||....|           |...|.........|:..  |.:.|.||
Human   226 LTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGP--ADDIKPCP 288

  Fly   293 RCSVTIEK--DGGCNHMVCKNQNCKNEFCWVCL 323
            |||..|.|  ||.||||.|....|  ||||:|:
Human   289 RCSAYIIKMNDGSCNHMTCAVCGC--EFCWLCM 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	20/64 (31%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	21/40 (53%)
RNF19B	NP_699172.2	Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death. /evidence=ECO:0000269\|PubMed:27485036	1..318		69/225 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112		3/10 (30%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	115..337		67/214 (31%)
		zf-RING_2	118..166	CDD:290367	18/51 (35%)
		IBR	187..251	CDD:214763	20/64 (31%)
		IBR	<283..321	CDD:279784	21/39 (54%)
		AzlC	<347..436	CDD:294385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..732
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810