DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-1 and Sharpin

DIOPT Version :9

Sequence 1:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_079616.2	Gene:	Sharpin / 106025	MGIID:	1913331	Length:	380	Species:	Mus musculus

Alignment Length:	147	Identity:	31/147 - (21%)
Similarity:	48/147 - (32%)	Gaps:	47/147 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EVDLPSSADRQMDQDDYQYKVLTTDEIVQHQREII---DEANLLLKLPTPTTRILLNHFKWDKEK 92
            |||||.|:..           ...:|:.....:.|   ||     |.......:|..|......:
Mouse   157 EVDLPQSSGN-----------FKKEELATRLSQAIAGGDE-----KAAAQVAAVLAQHHVALNVQ 205

  Fly    93 LLEKYF-----------DDNTD--EFFKCAHV---INPFNATEAIKQKTSRSQCEECEICFSQLP 141
            |:|.:|           :|.|.  .....|||   |:|..:..|::.:.           ||:..
Mouse   206 LMEAWFPPGPIRLQVTVEDATSVLSSSSSAHVSLKIHPHCSIAALQDQV-----------FSEFG 259

  Fly   142 -PDSMAGLECGHRFCMP 157
             |.::.....|...|||
Mouse   260 FPPAVQRWVIGRCLCMP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-1	NP_001245736.1	IBR	204..264	CDD:214763
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784
Sharpin	NP_079616.2	Self-association. /evidence=ECO:0000250\|UniProtKB:Q9EQL9	1..177		7/30 (23%)
		Sharpin_PH	16..125	CDD:293369
		Interaction with SHANK1. /evidence=ECO:0000250\|UniProtKB:Q9EQL9	172..305		24/121 (20%)
		UBQ	218..297	CDD:294102	15/70 (21%)
		zf-RanBP	345..369	CDD:279035
		RanBP2-type Zn finger	345..364	CDD:275376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900