DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wupA and TNNI2

DIOPT Version :9

Sequence 1:	NP_728142.1	Gene:	wupA / 32794	FlyBaseID:	FBgn0283471	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_001139301.1	Gene:	TNNI2 / 7136	HGNCID:	11946	Length:	182	Species:	Homo sapiens

Alignment Length:	176	Identity:	57/176 - (32%)
Similarity:	96/176 - (54%)	Gaps:	17/176 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RKKKLRLLLRKKAAEELKKEQERKAAERRRIIEERCGSPRNLSDASEGELQEICEEYYERMYICE 168
            |::.|:.::.:.||.||:||:.|:.||::..:.|.| .|.:: ..|..|:||:|::.:.::...|
Human    14 RRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHC-PPLHI-PGSMSEVQELCKQLHAKIDAAE 76

  Fly   169 GQKWDLEYEVRKKDWEINDLNAQVNDLRGKFVKPALKKVSKYENKFAKL---QKKAAEFNFRNQL 230
            .:|:|:|..|:|...|:.|:|.::.||||||.:|.|::|....:...|.   .|.....:.|..|
Human    77 EEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANL 141

  Fly   231 KVVKKKEFTLEEEEKEKK----PDWSKG---KPGDAKVKEEVEAEA 269
            |.|||     |:.|||:.    .||.|.   |.|....|:..|:|:
Human   142 KQVKK-----EDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wupA	NP_728142.1	Troponin	116..233	CDD:395788	40/119 (34%)
TNNI2	NP_001139301.1	Involved in binding TNC	2..48		11/33 (33%)
		Troponin	15..145	CDD:366404	41/131 (31%)
		Involved in binding TNC and actin	97..117		10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151630
Domainoid	1	1.000	75	1.000	Domainoid score	I9066
eggNOG	1	0.900	-	-		E1_KOG3977
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5120
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1566919at2759
OrthoFinder	1	1.000	-	-		FOG0000525
OrthoInspector	1	1.000	-	-		otm41636
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2854
SonicParanoid	1	1.000	-	-		X413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890