Protein Alignment Mvb12 and Mvb12a

DIOPT Version :10

• Sequence 1: NP_573268.1
• Gene: Mvb12 / 32791
• FlyBaseID: FBgn0030894
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_082893.1
• Gene: Mvb12a / 73711
• MGIID: 1920961
• Length: 271
• Species: Mus musculus
• Alignment Length: 315
• Identity: 83/315 - (26%)
• Similarity: 124/315 - (39%)
• Gaps: 71/315 - (22%)

  Fly    54 DNRPITSLHIVEDFERCPKNFSAISRTYDQDSDADLWRDYSLFGR---QNTRY-LCLSKSEGLPE 114
            |:.|:..|.........|..||||:.|.:..:        :.|||   |...| |||| :.|:||
Mouse     6 DSAPLAGLVWSSASAPPPPGFSAITCTVEGGT--------ASFGRGFAQKAGYFLCLS-TLGIPE 61

  Fly   115 ----YVVETLQVISDKTPPPKEFSQVSRTADSDQKAWRKRQLIYKLSKRGTVTQAVTDIILCSKL 175
                .||..:|::.||.|.|..||.|:...|......:|:::..||...||....|:|:.|..|.
Mouse    62 NPQDNVVVDMQIVMDKGPLPSGFSAVNDPQDIKASVSKKKRMCVKLMPLGTADVVVSDVKLSGKT 126

  Fly   176 KAAPDGFKLAGDINGVLI-CYKTSAIPVRLSPPVPGGGLPAPATCEVEQALNRLNLQGQRNSRGP 239
            |..| |:...|||.|..| |.|:.|       |.|   :|.|.|  :.|.:..|:|
Mouse   127 KTVP-GYLRVGDIGGFAIWCKKSKA-------PRP---VPKPRT--LSQDMRGLSL--------- 169

  Fly   240 LPQPPTEHHDYEEIQANYQINSPQRPAPPRPAGVGSGGGHGTYGGT------GTLGTYTELEGVP 298
              .||.|               |.:.:.|.......|....|...|      .:|...:.::|||
Mouse   170 --DPPKE---------------PSKGSHPERTLSRLGSRASTLRRTDSIYEASSLYGISAMDGVP 217

  Fly   299 FVMDVRLQRN-------QAVNDIPTLPEISTLLKSLDYDFQLERQILCTMKSSAS 346
            |.:..|.:..       .|..|: |:..::.:.|..:|.|.:|:.....:..|.|
Mouse   218 FTLHPRFEGKSCGPLNLSAFGDL-TIKSLADIEKEYNYGFVVEKTAAARLPPSVS 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mvb12	NP_573268.1	DUF2464	56..334	CDD:463017	79/299 (26%)
Mvb12a	NP_082893.1	DUF2464	9..259	CDD:463017	79/298 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..192		15/80 (19%)
		SH3-binding	153..158		2/7 (29%)
		Interaction with TSG101, VPS37B and VPS28. /evidence=ECO:0000250	190..271		16/81 (20%)