DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP16F and ARHGAP12

DIOPT Version :10

Sequence 1:NP_001285400.1 Gene:RhoGAP16F / 32790 FlyBaseID:FBgn0030893 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_060757.4 Gene:ARHGAP12 / 94134 HGNCID:16348 Length:846 Species:Homo sapiens


Alignment Length:493 Identity:120/493 - (24%)
Similarity:197/493 - (39%) Gaps:155/493 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 CFRDRSTTSSSSSQAQHAYVRGHSVTSSTLFRLEGSGGSNCT-LDKAGKQDTGRPEAVVLLRELK 105
            ||.:..::.||..         |..|:|:....|..|..|.| :.:.||               |
Human   441 CFPENESSPSSPK---------HQDTASSPKDQEKYGLLNVTKIAENGK---------------K 481

  Fly   106 TRPNKL---ALLKSSSSKDLTRLFL-DDSTNTAVLVSNTS------------IDVCSSNSSSGGS 154
            .|.|.|   |:|:.||     .||. ...::|:...||.|            |::.|.:.||   
Human   482 VRKNWLSSWAVLQGSS-----LLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSS--- 538

  Fly   155 PAVGRSKSGRDRRNGLECCSSCSKRWHDLKQRMHTLEQDLLVQ----------------TTYSQE 203
                                  .|...:||.|..|   :||:|                |..:|.
Human   539 ----------------------KKNVFELKTRQGT---ELLIQSDNDTVINDWFKVLSSTINNQA 578

  Fly   204 LEQKVGEMSRQLTEL--LQERDRE---RDKDKAR-FAAAGGVAAPGKRTAHGSPNVRPSRLVAWM 262
            :|...| :..::.:.  :::.|:|   :|..|.| |..:...::..|:|.              .
Human   579 VETDEG-IEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTK--------------K 628

  Fly   263 NLSNWFKSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPI 327
            ||..:...||:::.:||:....|: .|.:.|..:.:. ::.|||:.|..|.:.:|:    ....|
Human   629 NLKKFLTRRPTLQAVREKGYIKDQ-VFGSNLANLCQR-ENGTVPKFVKLCIEHVEE----HGLDI 687

  Fly   328 EGIYRQCGDYNKIQTLRFSIDANDYDSLRQPD-VDIHTLTGVLKLFLREIKSPLVRVNEAKTFIG 391
            :||||..|:...||.|||:::.::...|.... .|||.:||.||:|.||:..||...|....|:.
Human   688 DGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVN 752

  Fly   392 ----QPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRI------TKVPLQQIS---- 442
                :|.|        ::.::|.|||.||:.|:|||..:|.|..|:      .::..|.|:    
Human   753 AIKQEPRQ--------RVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFG 809

  Fly   443 -------AETLSISVTPSIFHTVPQGVHMQDIQQLLRE 473
                   .||.:|:|     |||.|.   |.::.:|.|
Human   810 PTLLKPEKETGNIAV-----HTVYQN---QIVELILLE 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP16FNP_001285400.1 RhoGAP 306..487 CDD:238090 58/190 (31%)
ARHGAP12NP_060757.4 SH3_ARHGAP12 15..74 CDD:213003
SH3-WW_linker 71..266 CDD:435468
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 152..241
PRP40 259..>412 CDD:227435
WW 268..298 CDD:238122
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..316
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..466 7/33 (21%)
PH_ARHGAP9-like 465..576 CDD:270053 33/158 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 580..629 10/63 (16%)
RhoGAP_ARHGAP27_15_12_9 654..839 CDD:239868 61/205 (30%)
Blue background indicates that the domain is not in the aligned region.

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