Protein Alignment RhoGAP16F and BEM2

DIOPT Version :9

• Sequence 1: NP_001285400.1
• Gene: RhoGAP16F / 32790
• FlyBaseID: FBgn0030893
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_011082.3
• Gene: BEM2 / 856899
• SGDID: S000000957
• Length: 2167
• Species: Saccharomyces cerevisiae
• Alignment Length: 560
• Identity: 113/560 - (20%)
• Similarity: 195/560 - (34%)
• Gaps: 161/560 - (28%)

  Fly    19 HIVIGAAGFVAHERRQP----------------GKTLMNCFRD------RSTTSSSSSQAQHAYV 61
            :|:......:.:||..|                |:.|.|.|.|      :.|...|.|:|.....
Yeast  1653 NIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERF 1717

  Fly    62 RGHSVTSSTLFRLEGSGGSNCTLDKAGKQDTGRPEAVVLLRELKTRPNKLALLKSSSSKDLTRLF 126
            :...|.:..|..         .::|. |::..:.|  |||.:.|...|..||.::...|:
Yeast  1718 QEQGVFNEILVN---------EIEKI-KREARKLE--VLLDQEKILKNSAALHQAVPKKN----- 1765

  Fly   127 LDDSTNTAVLVSNTSIDVCSS---NSSSGGSPAVG----RSKSGRDRRNGLECCSS--------- 175
                 ..:|::|.|..|...|   |.::|.:|::|    .:.|.|:||:.....|:
Yeast  1766 -----RKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFSTNRSSVVSNS 1825

  Fly   176 ----CSKRWHDLKQRMHTLEQDLLVQTTYSQE--LEQKVGEMSRQLTELLQERDRERDKD----- 229
                .||:.....:|..::.......:.||..  |.|:|......|..:|.|.|..:..|
Yeast  1826 SHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSILPEVDSMQLHDLKPSY 1890

  Fly   230 -------------------KARFAAAGGVAAPGK----RTAHGSPNVRPSRLVAWMNLSNWFKSR 271
                               .|.:.|...|...|.    :||..|            :|:.|.|..
Yeast  1891 SLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSS------------DLTEWIKMI 1943

  Fly   272 PSVETLREQRIFF---------DEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPI 327
            .:     .:|..|         ....|...||.|.:. ::..:|.|||   .|:|:...|....:
Yeast  1944 KA-----SKRFSFHSKKYKGKTHNKIFGVPLEDVCER-ENTLIPTIVV---KLLEEIELRGLDEV 1999

  Fly   328 EGIYRQCGDYNKIQTLRFSID---ANDYDSLRQPD--VDIHTLTGVLKLFLREIKSPL---VRVN 384
             |:||..|....|..|:.:.|   |.|.....:.|  .:::.:.|..|::|||:...|   ..||
Yeast  2000 -GLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAIAGCFKMYLRELPDSLFSHAMVN 2063

  Fly   385 EAKTFIGQPNQWLLTDLSAKLDS-----------LKRLIRSLPESNRDTMDYIFGHFNRITK-VP 437
            :            .|||:.|..:           :..|::.||.....|:..|..|.|::.: |.
Yeast  2064 D------------FTDLAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQTLKRIVFHLNKVHQHVV 2116

  Fly   438 LQQISAETLSISVTPSIFH----TVPQGVHMQDIQQLLRE 473
            ..::.|..|:|..:.|..:    ....|..:..:|.:|::
Yeast  2117 NNKMDASNLAIVFSMSFINQEDLANSMGSRLGAVQTILQD 2156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	44/192 (23%)
BEM2	NP_011082.3	RasGEF	592..860	CDD:214539
		REM	1120..1291	CDD:413353
		PH	<1877..1948	CDD:395117	13/87 (15%)
		RhoGAP	1981..2134	CDD:395495	41/168 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000