DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and RGA2

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	561	Identity:	109/561 - (19%)
Similarity:	186/561 - (33%)	Gaps:	173/561 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QTTTSQRPVTPGTPDS---------------------AHIVIGAAGFVAHERRQPGKTLMNCFRD 45
            ::...:.||:.|..||                     |...:|:..    :::....|..|...:
Yeast   484 KSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLGSIS----KKQNSNDTATNRRIN 544

  Fly    46 RSTTSSSSSQAQH-AYVRGHSVTSSTLFR---------------LEGSGGSNCTL-DKAGKQDTG 93
            .|.|||||  ..| |..|...:.|..||:               |:.|..:|..| |.:.|.|..
Yeast   545 GSFTSSSS--GHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDAT 607

  Fly    94 RPEAVVL----------LRELKTRPNKLALLKSSSSKDLTRLFL---------DDSTNTAVLVSN 139
            ...|..|          ||:||....:|...|....:|:..|.|         |:.|......|.
Yeast   608 DESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQSA 672

  Fly   140 TSIDVCSSNSSSGGSPAVGRSKSGRDRRNGLECCSSCSKRWHDLKQRMHTLEQDLLVQTTYSQEL 204
            :|.:......:...|..|....|..||:..:...|...:.|                 ..:|...
Yeast   673 SSRESLEQKENIATSITVKSPSSNSDRKGSISNASPKPRFW-----------------KIFSSAK 720

  Fly   205 EQKVGEMSRQLTELLQERDRERDKDKARFAAAGG--------------------VAAPGKRTAHG 249
            :.:||::..|              .::..:::||                    :.:|||...
Yeast   721 DHQVGDLESQ--------------QRSPNSSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPL-- 769

  Fly   250 SPNVRPSRLVAWMNLSNWFKSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCD 314
            ||:  |.||....:.|:.:.|........|:                      .|||.|:..|.|
Yeast   770 SPS--PKRLDYTPDGSHLYGSSLQARCAYEK----------------------STVPIIIRCCID 810

  Fly   315 LIEQKYRRSTQPIEGIYRQCGDYNKIQTLRFSIDAND--YDSLRQPDV------DIHTLTGVLKL 371
            .||:.  .....:||:||:.|....::.:......|:  :.....|.:      |||.:..|||.
Yeast   811 RIEKD--DIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKR 873

  Fly   372 FLREIKSP------------LVRVNEA--------KTFIGQPNQWLLTDLSAKLDSLKRLIRSLP 416
            :||::..|            |||.|:.        ..|:..|.:  :|.....|.||..:.:.||
Yeast   874 YLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQK--VTIYEMVLKSLLEIFKILP 936

  Fly   417 ESNRDTMDYIFGHFNRITKVPLQQI-SAETLSISVTPSIFH 456
            ..:::.:..:..|..::.:...:.: :...||:...||:.|
Yeast   937 VEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIH 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	40/180 (22%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		RhoGAP	815..1002	CDD:214618	34/167 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100