Protein Alignment RhoGAP16F and Arhgap12

DIOPT Version :9

• Sequence 1: NP_001285400.1
• Gene: RhoGAP16F / 32790
• FlyBaseID: FBgn0030893
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: XP_006526377.1
• Gene: Arhgap12 / 75415
• MGIID: 1922665
• Length: 843
• Species: Mus musculus
• Alignment Length: 611
• Identity: 136/611 - (22%)
• Similarity: 221/611 - (36%)
• Gaps: 192/611 - (31%)

  Fly     4 TTSQRPVTPGTPDSAHIVIGAAGFVAHERRQPGKTLMN----CFRDRSTTSSSSSQ--------A 56
            ||.:|...|  |..|..|..:..|.:...::|..:..|    ||      |.|.||        :
Mouse   285 TTQERTWKP--PRWARDVSTSRDFQSPGEQEPLSSEENYHSSCF------SQSDSQCGSPPRGWS 341

  Fly    57 QHAYVRGHSVTSS-----------------------------TLFRLEGSGGSNCTLDKAGKQDT 92
            :....|||::.:|                             .|.:...|......:.|:...|.
Mouse   342 EELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDR 406

  Fly    93 GRPEAVVLLRELKTRPNKLALLKSSSSKDLTRLFLDDSTNTAVLVSNTSIDVCSSNSSSGGSPAV 157
            ...|.:||   .|.|.:.:.|  .|:.||      ..:|....|..|.|....|.:....|| ..
Mouse   407 RLQEPIVL---TKWRHSTIVL--DSNDKD------SPTTTKLCLPENESPPTSSKHQDPAGS-LK 459

  Fly   158 GRSKSG------------RDRRNGL---------------------------------------- 170
            |:.|.|            :.|:|.|
Mouse   460 GQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGA 524

  Fly   171 --ECCS---SCSKRWHDLKQRMHTLEQDLLVQT-----------TYSQELEQKVGEMSRQLTEL- 218
              |..|   |..|...:||.|..|   :||:|:           ..|..:..:|.|......|.
Mouse   525 VIEMASKDKSSKKNVFELKTRQGT---ELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEET 586

  Fly   219 -----LQERDRERDKDKARFAAAGGVAAPGKRTAHGSPNVRPSRLVAWMNLSNWFKSRPSVETLR 278
                 :::.|:|:|:.:.:          ..|:..||......:.....||..:...||:::.:|
Mouse   587 PDSPGVEKHDKEKDQKELK----------KLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVR 641

  Fly   279 EQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPIEGIYRQCGDYNKIQTL 343
            |:....|: .|.:.|..:.:. ::.|||:.|..|.:.:|:    ....::||||..|:...||.|
Mouse   642 EKGYIKDQ-VFGSNLANLCQR-ENGTVPKFVKLCIEHVEE----HGLDVDGIYRVSGNLAVIQKL 700

  Fly   344 RFSIDANDYDSLRQPD-VDIHTLTGVLKLFLREIKSPLVRVNEAKTFIG----QPNQWLLTDLSA 403
            ||:::.::...|.... .|||.:||.||:|.||:..||...|....|:.    :|.|
Mouse   701 RFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQ-------- 757

  Fly   404 KLDSLKRLIRSLPESNRDTMDYIFGHFNRI------TKVPLQQIS-----------AETLSISVT 451
            ::.::|.|||.||:.|:|||..:|.|..|:      .::..|.|:           .||.:|:|
Mouse   758 RVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAV- 821

  Fly   452 PSIFHTVPQGVHMQDIQQLLREGETL 477
                |||.|.   |.::.:|.|..|:
Mouse   822 ----HTVYQN---QIVELILLELSTV 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	58/194 (30%)
Arhgap12	XP_006526377.1	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:374675
		PRP40	257..>409	CDD:227435	24/131 (18%)
		WW	266..296	CDD:238122	5/12 (42%)
		PH_ARHGAP9-like	462..573	CDD:270053	17/113 (15%)
		RhoGAP_ARHGAP27_15_12_9	651..836	CDD:239868	60/205 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1079
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930