DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and arhgap27

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_005156083.1	Gene:	arhgap27 / 564211	ZFINID:	ZDB-GENE-030131-3922	Length:	999	Species:	Danio rerio

Alignment Length:	472	Identity:	116/472 - (24%)
Similarity:	191/472 - (40%)	Gaps:	113/472 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SSSSSQAQHAYVRGHSVTSSTLFRLEGSGGSNCTLDKAGKQDTGRPEAVVLLRELKTRPN----- 109
            ::|.|:|..:....|:|::     ||.:|    .|:|....:.|:          |.|.|
Zfish   594 NTSDSEASSSPDTPHNVSN-----LEKAG----ILNKTKVSENGK----------KVRKNWGHSW 639

  Fly   110 ------KLALLKSSSSKDLTRLFLDDSTNTAVLVSNTSIDVCSSNSSSGGSPAVGRSKSGRDR-- 166
                  ||...|...|..     ...|:.|..::...::|:  ..::...:|   :.||.:..
Zfish   640 TVLHGGKLTFHKDPKSTP-----AGASSKTNQILPEFTVDL--KGATINRAP---KDKSSKKNVL 694

  Fly   167 ----RNGLEC-----CSSCSKRWHD-LKQRMHTLEQDLLVQTTYSQELEQKVGEMSRQLTELLQE 221
                |.|.|.     ..|..:.||. :...:|.|..|     .:..|.|.:|.:.|..|
Zfish   695 ELKTRTGAEYLIQYDTDSIIQDWHKVILDTIHQLNGD-----QHHSEEEDEVIDKSPTL------ 748

  Fly   222 RDR-ERDKDKARFAAAGGVAAPGKRTAHGSPNVRPSRLVAWMNLSNWFKSRPSVETLREQRIFFD 285
             || ||..:|...:.|....:....:......||       ..|..:...||::::::::. :..
Zfish   749 -DREERPFEKRTMSTATRQPSTSSTSEAEQKKVR-------TKLKKFLLKRPTLQSVKDKG-YIR 804

  Fly   286 EPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPIEGIYRQCGDYNKIQTLRFSIDAN 350
            |..|...|..:...::.| ||..|..|...:|   :|..: |:|:||..|:...||.|||..|..
Zfish   805 ENVFGCHLHNLCSQEKTR-VPSFVEKCIRAVE---KRGLE-IDGLYRVSGNLAVIQKLRFKADHE 864

  Fly   351 DYDSLRQPDVDIHTLTGVLKLFLREIKSPLVRVNEAKTF---IGQPNQWLLTDLSAKLDSLKRLI 412
            |.| |.:.:.|||.:||.||||.||::.||...|....|   |..|      |..:|:..::.|:
Zfish   865 DLD-LEEGNWDIHVITGALKLFFRELQEPLFPYNLFNEFICAIKTP------DYYSKISHMRNLV 922

  Fly   413 RSLPESNRDTMDYIFGHFNRI------TKVPLQQIS-----------AETLSISVTPSIFHTVPQ 460
            ||||..|.|||:.:|.|..|:      .::.:|.::           .||.||: |..:|..
Zfish   923 RSLPPPNHDTMEALFSHLRRVIQHGNENRMTVQNVAIVFGPTLLKPEEETASIA-TYMVFQN--- 983

  Fly   461 GVHMQDIQQLLREGETL 477
                |.::.||.|.|::
Zfish   984 ----QIVEFLLSEFESI 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	62/192 (32%)
arhgap27	XP_005156083.1	SH3	22..77	CDD:302595
		WW	315..343	CDD:278809
		WW	382..410	CDD:278809
		PH	613..726	CDD:278594	25/136 (18%)
		PH_ARHGAP9-like	614..725	CDD:270053	24/134 (18%)
		RhoGAP_ARHGAP27_15_12_9	808..992	CDD:239868	64/203 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1079
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030