DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and arhgap22

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_690970.4	Gene:	arhgap22 / 562503	ZFINID:	ZDB-GENE-090313-87	Length:	698	Species:	Danio rerio

Alignment Length:	369	Identity:	86/369 - (23%)
Similarity:	146/369 - (39%)	Gaps:	96/369 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SSNSSSGGSPAVGRS--KSGRDRRNGLECCSSCSKRWHDLKQRMHTLEQDLL------------- 195
            |..||...||::...  |:|     .|:...|..|.|   :.|...|..|.|
Zfish    26 SRGSSRPSSPSLQEQVVKAG-----WLKKQRSIMKNW---QLRWFVLRTDHLYFYKDEEETKPQG 82

  Fly   196 ---VQTTYSQELEQKVGEMSRQLTELLQ----ERDRERDKDKARFAAAGGVAAPGKRTAHGSPNV 253
               :|.:...||.....|..|.|.|::.    |:||.....:|....|            .|.|
Zfish    83 CIPLQGSQVNELTANPDEPGRHLFEIVPGCTGEKDRSALSHEAFLLMA------------NSQN- 134

  Fly   254 RPSRLVAWMNLSNWFKSRPSVETLREQRIF---FDEPCFDTELEMVLKHDQH---RTVPRIVVDC 312
                     ::.:|.|:        .:|:.   |....|...||..:::::.   |..|.:|..|
Zfish   135 ---------DMEDWVKA--------IRRVIWAPFGGGIFGQHLEDTVQYERKFGPRLAPLLVEQC 182

  Fly   313 CDLIEQKYRRSTQPIEGIYRQCGDYNKIQTLRFSIDAND---YDSLRQPDVDIHTLTGVLKLFLR 374
            .|.|.::..:.    ||::|..|..|.::.|:.:.|..|   :||    :.|:||:..:|||:||
Zfish   183 VDFIREQGLKE----EGLFRMPGQANLVKELQDAFDCGDKPLFDS----NTDVHTVASLLKLYLR 239

  Fly   375 EIKSPLVRVNEAKTFIGQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIF-------GHFNR 432
            |:..|::..|:.:.|: ...|.||.|....|..|.:.:.:||::|.:.:.||.       .|.|.
Zfish   240 ELPEPVIPFNKYEDFL-TCAQLLLKDEEMGLGELVKQVSTLPQANYNLLKYICKFLDEVQSHSNE 303

  Fly   433 ITKVPLQQISAETLSISVTPSIFH-TVPQGVHMQD----IQQLL 471
                  .::|.:.|:....|:|.. .:...|.|.:    :|||:
Zfish   304 ------NKMSVQNLATVFGPNILRPKIEDPVSMMEGTTQVQQLM 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	49/181 (27%)
arhgap22	XP_690970.4	PH-like	39..154	CDD:302622	28/152 (18%)
		PH	41..147	CDD:278594	27/143 (19%)
		RhoGAP_ARHGAP22_24_25	154..352	CDD:239855	53/203 (26%)
		BAR	<577..>683	CDD:299863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000