DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP16F and ARHGAP15

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_060930.3	Gene:	ARHGAP15 / 55843	HGNCID:	21030	Length:	475	Species:	Homo sapiens

Alignment Length:	497	Identity:	118/497 - (23%)
Similarity:	201/497 - (40%)	Gaps:	95/497 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 HERRQPGKTLMNCFRDRSTTSSSSSQAQHA-YVRGHSVTSSTLFRLEGSGGSNCTLDKAGKQDTG 93
            |:|....|:::.....:.|...|..:..|: ::....:.......:|..|    .|.||...|.|
Human    35 HDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEG----YLQKAKIADGG 95

  Fly    94 RPEAVVLLRELKTRPNKLALLKSSSSKDLTRLFLDDSTNTAVLVSNT-----SIDVCSSNSSSGG 153
            :          |.|.|........||:.:.  |..:|...|:....|     |:|:|.::
Human    96 K----------KLRKNWSTSWIVLSSRRIE--FYKESKQQALSNMKTGHKPESVDLCGAH----- 143

  Fly   154 SPAVGRSKSGRDRRNGLECCSSCSKR-------------W-HDLKQRMHTLEQDLLVQTTYSQEL 204
               :..:|....|:|..:..:.....             | |.:|..:..|.:|   .:..|:.|
Human   144 ---IEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKD---SSCPSRNL 202

  Fly   205 EQ-KVGEMSRQLTELLQERDRERDKDKARFAAAGGVAAPGKRTA-----HGSPNVRPSRLVAWMN 263
            |. |:...|.  ||||...|.:..:.|           |..|.:     |.|.:....:......
Human   203 ELFKIQRSSS--TELLSHYDSDIKEQK-----------PEHRKSLMFRLHHSASDTSDKNRVKSR 254

  Fly   264 LSNWFKSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPIE 328
            |..:...|||::||:|:.:..|: .|.:.|..|.:. ::.|||..|..|.:.:|::    ...::
Human   255 LKKFITRRPSLKTLQEKGLIKDQ-IFGSHLHKVCER-ENSTVPWFVKQCIEAVEKR----GLDVD 313

  Fly   329 GIYRQCGDYNKIQTLRFSIDANDYDSLRQPD---VDIHTLTGVLKLFLREIKSPLVRVNEAKTFI 390
            ||||..|:...||.|||.:  |..:.|...|   .|||.:||.||:|.||:..||...:..:.|:
Human   314 GIYRVSGNLATIQKLRFIV--NQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFV 376

  Fly   391 GQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRI-TKVPLQQISAETLSISVTPSI 454
            ....:   .|.:.:::::|.|::.||..|||||..:|||..:| .|.....:|.::|.|...|::
Human   377 EAIKK---QDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTL 438

  Fly   455 F----HTVPQGVHMQDIQQLLREGETLADCVKLMIEYQGRIF 492
            .    .|....:||....|:          .:||:....:||
Human   439 LRAENETGNMAIHMVYQNQI----------AELMLSEYSKIF 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	55/188 (29%)
ARHGAP15	NP_060930.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		PH	80..188	CDD:278594	25/131 (19%)
		PH_ARHGAP9-like	81..190	CDD:270053	25/132 (19%)
		RhoGAP_ARHGAP27_15_12_9	279..465	CDD:239868	60/205 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4483
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860