DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and Arhgap27

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001192165.1	Gene:	Arhgap27 / 544817	MGIID:	1916903	Length:	869	Species:	Mus musculus

Alignment Length:	472	Identity:	110/472 - (23%)
Similarity:	185/472 - (39%)	Gaps:	119/472 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 TLDKAGKQDTGRPEAVVLLRELKTRPNKLALLKSSSSKDLTRL------FLDDSTNTAV------ 135
            ||||||           :|...||......|.|...|...|.|      |..||..:|.
Mouse   477 TLDKAG-----------VLHRTKTVDKGKRLRKKHWSTSWTVLEGGVLTFFKDSKTSAAGGLRQP 530

  Fly   136 -LVSNTSIDVCSSNSSSGGSPAVGRSKSGRDRRNGLECCSSCSKRW---HDLKQRMHTLEQDLLV 196
             .:|.....|....:|...:|     |....::|.||..|.....:   ||.:          .:
Mouse   531 SKLSTPEYTVELKGASLSWAP-----KDKSSKKNVLELRSRDGSEYLIQHDSE----------AI 580

  Fly   197 QTTYSQELEQKVGEMSRQLTELLQERDRE---------------RDKDKARFAAA-----GGVAA 241
            .:|:.:.:.:.:.|:|   .:|||..:.|               |::|..:.||:     ||:.:
Mouse   581 ISTWHKAIAEGISELS---ADLLQGEEGEPSSADFGSSERLGSWREEDVRQNAASPSLSPGGLES 642

  Fly   242 PGKRTAHGSPNVRPSRLVAWMNLSNWFKSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVP 306
            ...|..|              .|..:.:.||::::||::....|: .|...|..:.:.:: ..||
Mouse   643 DLSRVRH--------------KLRKFLQRRPTLQSLRDKGYIKDQ-VFGCALAQLCERER-SPVP 691

  Fly   307 RIVVDCCDLIEQKYRRSTQPIEGIYRQCGDYNKIQTLRFSIDAN---DYDSLRQPDVDIHTLTGV 368
            |.|..|...:|.:    ...|:|:||..|:...||.||:.:|.:   |.|..|..||  |.:||.
Mouse   692 RFVQQCIRTVEAR----GLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDV--HVITGA 750

  Fly   369 LKLFLREIKSPLVRVNEAKTFIGQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRI 433
            ||||.||:..||...:....||....   |.|.:.:...::.|:|:||..|:||:..:..|..|:
Mouse   751 LKLFFRELPEPLFPFSHFHQFIAAIK---LQDPAQRSRCVRDLVRTLPAPNQDTLRLLIQHLCRV 812

  Fly   434 TKVPLQ-QISAETLSISVTPSIFHTVPQGVHMQDIQQLLREGETLADCVKLMIEYQGRIFDRLRL 497
            .:...| :::.:.::|...|:                |||.....|.....|: :|.::.:.
Mouse   813 IEHGEQNRMTVQNVAIVFGPT----------------LLRPEMEEASMPMTMV-FQNQVVEL--- 857

  Fly   498 IQTAHLLCRCVERFANH 514
                 :|.:|.:.|..|
Mouse   858 -----ILHQCADIFPPH 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	52/184 (28%)
Arhgap27	NP_001192165.1	SH3_ARHGAP27	10..66	CDD:213002
		PRK12323	<68..249	CDD:237057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..300
		PRP40	241..>328	CDD:227435
		WW	248..278	CDD:395320
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..401
		WW	418..445	CDD:395320
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..477		110/472 (23%)
		PH_ARHGAP9-like	480..594	CDD:270053	27/139 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..642		5/18 (28%)
		RhoGAP_ARHGAP27_15_12_9	675..861	CDD:239868	57/220 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1079
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840