DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and Arhgap27

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_942054.1	Gene:	Arhgap27 / 303583	RGDID:	735202	Length:	869	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	108/460 - (23%)
Similarity:	182/460 - (39%)	Gaps:	95/460 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 TLDKAGKQDTGRPEAVVLLRELKTRPNKLALLKSSSSKDLTRL------FLDDSTNTAV------ 135
            ||||||           :|...||......|.|...:...|.|      |..||..:|.
  Rat   477 TLDKAG-----------VLHRTKTVDKGKRLRKKHWNASWTVLEGGVLTFFKDSKTSAASGLRQP 530

  Fly   136 -LVSNTSIDVCSSNSSSGGSPAVGRSKSGRDRRNGLECCSSCSKRW---HDLKQRMHTLEQDLLV 196
             .:|.....|....:|...:|     |....::|.||..|.....:   ||.:          .:
  Rat   531 SKLSTPEYTVELRGASLSWAP-----KDKSSKKNVLELRSRDGSEYLIQHDSE----------AI 580

  Fly   197 QTTYSQELEQKVGEMSRQLTELLQERDRERDKDKARFAAA---GGVAAPGKRTAHGSPNVRPSRL 258
            .:|:.:.:.:.:.|:|..|.:     ..|.:...|.|.::   |.......|....||::.|...
  Rat   581 ISTWHKAIAEGIEELSADLPQ-----REEGEPSSADFGSSERLGSWKEEDVRPNAASPSLNPGSQ 640

  Fly   259 VAWMN-----LSNWFKSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQ 318
            .:.::     |..:.:.||::::|||:....|: .|...|..:.:.:: ..|||.|..|...:|.
  Rat   641 ESDLSRVRHKLRKFLQRRPTLQSLREKGYIKDQ-VFGCALAQLCERER-SPVPRFVQQCIRTVEA 703

  Fly   319 KYRRSTQPIEGIYRQCGDYNKIQTLRFSIDAN---DYDSLRQPDVDIHTLTGVLKLFLREIKSPL 380
            :    ...|:|:||..|:...||.||:.:|.:   |.|..|..||  |.:||.||||.||:..||
  Rat   704 R----GLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDV--HVITGALKLFFRELPEPL 762

  Fly   381 VRVNEAKTFIGQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAE 444
            ...:....||....   |.|.:.:...::.|:|:||..|.||:..:..|..|:.:...| ::|.:
  Rat   763 FPFSHFHQFIAAIK---LQDPAQRSRCVRDLVRTLPAPNHDTLRLLIQHLCRVIEHGEQNRMSVQ 824

  Fly   445 TLSISVTPSIFHTVPQGVHMQDIQQLLREGETLADCVKLMIEYQGRIFDRLRLIQTAHLLCRCVE 509
            .::|...|:                |||.....|.....|: :|.::.:.        :|.:|.:
  Rat   825 NVAIVFGPT----------------LLRPEMEEASMPMTMV-FQNQVVEL--------ILHQCAD 864

  Fly   510 RFANH 514
            .|..|
  Rat   865 IFPPH 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	53/184 (29%)
Arhgap27	NP_942054.1	SH3	10..66	CDD:302595
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..137
		WW	248..278	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..299
		WW	301..328	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..389
		WW	418..445	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..474
		PH_ARHGAP9-like	480..594	CDD:270053	26/139 (19%)
		PH	480..593	CDD:278594	26/138 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..644		9/50 (18%)
		RhoGAP_ARHGAP27_15_12_9	675..861	CDD:239868	58/220 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1079
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840