Protein Alignment RhoGAP16F and ARHGAP27

DIOPT Version :10

• Sequence 1: NP_001285400.1
• Gene: RhoGAP16F / 32790
• FlyBaseID: FBgn0030893
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: XP_011522770.1
• Gene: ARHGAP27 / 201176
• HGNCID: 31813
• Length: 922
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 116/494 - (23%)
• Similarity: 185/494 - (37%)
• Gaps: 129/494 - (26%)

  Fly    83 TLDKAGKQDTGRPEAVVLLRELKTRPNKLALLKSSSSKDLTRL------FLDDSTNTAV--LVSN 139
            ||||||           :|...||......|.|...|...|.|      |..||..:|.  |...
Human   496 TLDKAG-----------VLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQP 549

  Fly   140 TSIDVCSSNSSSGGSPAVGRSKSGRDRRNGLECCSSCSKRW---HDLKQRMHTLEQDLLVQTTYS 201
            :............|:......|....|:|.||..|.....:   ||.:          .:.:|:.
Human   550 SKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSE----------AIISTWH 604

  Fly   202 QELEQKVGEM-SRQLTELLQERDRERDKDKARFAAAGGVA--------APGKRTAHGSPNVRPS- 256
            :.:.|.:.|: |.||          |:.:..|....|..|        |.|.::|...|....|
Human   605 KAIAQGIQELGSMQL----------REVNVLRLTGGGPAAGSRPRLSEAMGIQSAELPPEESESS 659

  Fly   257 --------RLVAWM-----------------------------NLSNWFKSRPSVETLREQRIFF 284
                    ||.:|.                             .|..:.:.||::::|||:....
Human   660 RVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIK 724

  Fly   285 DEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPIEGIYRQCGDYNKIQTLRFSIDA 349
            |: .|...|..:.:.::.| |||.|..|...:|.:    ...|:|:||..|:...||.||:.:|.
Human   725 DQ-VFGCALAALCERERSR-VPRFVQQCIRAVEAR----GLDIDGLYRISGNLATIQKLRYKVDH 783

  Fly   350 N---DYDSLRQPDVDIHTLTGVLKLFLREIKSPLVRVNEAKTFIGQPNQWLLTDLSAKLDSLKRL 411
            :   |.|..|..||  |.:||.||||.||:..||...:..:.||....   |.|.:.:...::.|
Human   784 DERLDLDDGRWEDV--HVITGALKLFFRELPEPLFPFSHFRQFIAAIK---LQDQARRSRCVRDL 843

  Fly   412 IRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHTVPQGVHMQDIQQLLREGE 475
            :||||..|.||:..:|.|..|:.:...| ::|.::::|...|:                |||. |
Human   844 VRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPT----------------LLRP-E 891

  Fly   476 TLADCVKLMIEYQGRIFDRLRLIQTAHLLCRCVERFANH 514
            .....:.:.:.:|.::.:.        :|.:|.:.|..|
Human   892 VEETSMPMTMVFQNQVVEL--------ILQQCADIFPPH 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	54/184 (29%)
ARHGAP27	XP_011522770.1	SH3_ARHGAP27	10..66	CDD:213002
		PRP40	239..>376	CDD:227435
		WW	247..278	CDD:459800
		WW	415..442	CDD:459800
		PH_ARHGAP9-like	499..613	CDD:270053	27/134 (20%)
		RhoGAP_ARHGAP27_15_12_9	728..914	CDD:239868	60/220 (27%)