DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP16F and tag-325

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001309440.1	Gene:	tag-325 / 175636	WormBaseID:	WBGene00008006	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	525	Identity:	117/525 - (22%)
Similarity:	200/525 - (38%)	Gaps:	118/525 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TPGTPDSAHIVIGAAGFVAHERRQPGKTLMN--CFRDRST------------TSSSSSQAQHAYV 61
            |..||.:..:            |:|..|.:.  .|:::.|            |:|||......|
Worm   301 TSKTPTAIRV------------RRPSPTNLRSVSFQNKCTVLKNVPMPQVLPTTSSSFDHHPQY- 352

  Fly    62 RGHSVTSSTLFRLEGSG----GSNCTLDKAGKQDTGRPEAVVLLRELKTRPNKLALLKSSSSKDL 122
              ||.|......:|.|.    .|.|. ::.|..|...|...:...:|:...|.....|....|..
Worm   353 --HSNTPDRPILMEDSADFTPSSRCE-ERRGSGDGREPVRTIRCGDLERSENDEPAEKVVKPKKR 414

  Fly   123 TRLFLDDSTNTAVLVSNTSIDVCSSNSSSGGSPAVGRSKSGR--DRRNGLECCSSCSKRWHDLKQ 185
            ..:     ||...|.:...|......|:         .|.|:  |...|:......|..|:...:
Worm   415 EWI-----TNYMYLTTAHLILYKDQKSA---------EKHGKHYDAPQGVWDLRGASVTWYQDNR 465

  Fly   186 RMHTLEQDLLVQ-------------------TTYSQELEQKVGEM-------------------- 211
            .:...:|...:|                   ..:.:.||:.|.::
Worm   466 DVQKKKQRKYIQLELCNTKKYLLRGPNDTEAVEWYKSLEEVVAKLPSPGSSNQPMIDVTNGVARN 530

  Fly   212 ------SRQLTELL--QERDRERDKDKARFAAAGGVAAPGKRTAHGSPNVRPSRLVAWMNLSNWF 268
                  :|.|:..|  ..|...|..|....:|...|:     |:..:...|||:......|..:|
Worm   531 PSYIGSTRPLSHALIPISRSMRRRDDPMSQSAIETVS-----TSVSTDEPRPSKETIIEKLRRFF 590

  Fly   269 KSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPIEGIYRQ 333
            ::||:||:|:|:.|:..||.|.:.|..:.:| ::..||:.:....::||.|...:    :||||.
Worm   591 RTRPTVESLKEKGIYKPEPVFGSTLSAICQH-ENSLVPKFIRVITEVIESKGLET----DGIYRV 650

  Fly   334 CGDYNKIQTLRFSIDANDYDSLRQPDVDIHTLTGVLKLFLREIKSPLVRVNEAKTF---IGQPNQ 395
            .|:.:.:|.:|...|.::|.:|...: |||.|||.||||.||:..||..::..|.:   :..||
Worm   651 SGNLSAVQKIRCQADQDNYKALVSEE-DIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQMPN- 713

  Fly   396 WLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHTVP 459
                 .:.:....:.|:..||..||:|:..:..|.||:.....| ::....|:|...|::||...
Worm   714 -----ATTRFKKFEELLSRLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLAIVFGPTLFHNGD 773

  Fly   460 QGVHM 464
            ..|::
Worm   774 GAVNL 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	47/163 (29%)
tag-325	NP_001309440.1	WW	101..130	CDD:278809
		PH_ARHGAP9-like	391..509	CDD:270053	20/131 (15%)
		PH	407..508	CDD:278594	17/114 (15%)
		RhoGAP_ARHGAP27_15_12_9	611..825	CDD:239868	51/180 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1079
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910