DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and arhgap15

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_017952790.2	Gene:	arhgap15 / 100485536	XenbaseID:	XB-GENE-6038823	Length:	550	Species:	Xenopus tropicalis

Alignment Length:	531	Identity:	121/531 - (22%)
Similarity:	192/531 - (36%)	Gaps:	168/531 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ERRQPGKTLMNCFRDRSTTSSSSSQAQHAYVRGHSVTSSTLFRLEGSGGSNCT--------LDKA 87
            ||....|:|:   .|.:|...|..:..|          |..|.|:.||..|..        |:|.
Frog   120 ERLCQAKSLV---LDEATKPISRHRRNH----------SQQFVLDTSGSENILVNRNKEGFLNKT 171

  Fly    88 GKQDTGRPEAVVLLRELKTRPN-----------KLALLKSSSSKDLTRLFLDDST-NTAVLVSNT 140
            ...:.|:          |.|.|           ||...|  .:||.|...|..|| ...:.:...
Frog   172 KIAEKGK----------KLRKNWVTSYTVLSGPKLEFYK--DAKDQTASDLRSSTKQERIDLRGA 224

  Fly   141 SIDVCSSNSS----------SGGS----------------------PAVGRSKSGRDRRNGLECC 173
            |::..:..||          ||..                      .::||.|........:|..
Frog   225 SVEWANEKSSRKNVFQITTLSGNEFLFQSDADITVQEWFRAIRNTIDSLGREKKSPPLCGNIEKT 289

  Fly   174 SSCS---KRWHDLKQRMHTLEQDLLVQTTYSQELEQKVGEMSRQLTELLQERDRERDKDKARFAA 235
            |:..   ....:.|:..|...:.|:.:..||      ..:.|            ||::.|.|
Frog   290 SNIELLHLEGENTKEHKHEQRKSLIFKLNYS------ASDTS------------ERNRVKTR--- 333

  Fly   236 AGGVAAPGKRTAHGSPNVRPSRLVAWMNLSNWFKSRPSVETLREQRIFFDEPCFDTELEMVLKHD 300
                                        |..:...|||::||:|:.|..|: .|...||.:.|.
Frog   334 ----------------------------LKKFISRRPSLKTLQEKGIIKDQ-VFGCHLETLCKR- 368

  Fly   301 QHRTVPRIVVDCCDLIEQKYRRSTQPIEGIYRQCGDYNKIQTLRFSIDANDYDSLRQPDV---DI 362
            ::.||||.|..|.:.:|::    ....:||||..|:.:.||.|||.:  |..:.|...|.   ||
Frog   369 ENETVPRFVTQCIEAVEKR----GMDADGIYRVSGNLSTIQKLRFIV--NQEEKLNLDDSQWDDI 427

  Fly   363 HTLTGVLKLFLREIKSPLVRVNEAKTFIGQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIF 427
            |.:||.||:|.||:..||......:.|:   ....|.:...::.:|:.|:.:||.:||:||..:|
Frog   428 HVVTGALKMFFRELPEPLFPYRFFEQFV---EAIKLQESHLRVKALRDLVWNLPPANRNTMKALF 489

  Fly   428 GHFNRI-TKVPLQQISAETLSISVTPSIFHTVPQGVHMQDIQQLLREGETLADCVKLMIEYQGRI 491
            .|..:| .|..:..:|.::|.|...|:                |||....:.:....|: ||.:|
Frog   490 EHLRKIVAKASVNLMSTQSLGIVFGPT----------------LLRPESDMGNMAVCMV-YQNQI 537

  Fly   492 -------FDRL 495
                   ||::
Frog   538 VEIMLTEFDKI 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	52/184 (28%)
arhgap15	XP_017952790.2	PH_ARHGAP9-like	164..272	CDD:270053	20/119 (17%)
arhgap15	XP_017952790.2	RhoGAP_ARHGAP27_15_12_9	358..544	CDD:239868	61/212 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000