DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP16F and arhgap15

DIOPT Version :9

Sequence 1:	NP_001285400.1	Gene:	RhoGAP16F / 32790	FlyBaseID:	FBgn0030893	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001122027.1	Gene:	arhgap15 / 100003547	ZFINID:	ZDB-GENE-070912-314	Length:	465	Species:	Danio rerio

Alignment Length:	517	Identity:	114/517 - (22%)
Similarity:	188/517 - (36%)	Gaps:	146/517 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RDRSTTSSSSSQAQHAYVRGHSVTSSTLFRLEGSGG----SNCTLD------------KAGKQDT 92
            |::|..:|..|......::|..:..:.:    ..||    .|.||.            |..||:.
Zfish    51 RNQSQHNSEVSVGLQPVLKGEYLNKAKI----AEGGKKLRKNWTLTWVVLSSNQLLFYKESKQEA 111

  Fly    93 -------GRPEAVVL-------LRELKTRPNKLALLKSSSSKDLTRLFLDDSTNTAVL-----VS 138
                   |:|:.|.|       ..|..:|.|.:.:...:..:     ||..:.:...:     ..
Zfish   112 VSNLKPGGKPDGVDLNGAVIEWTTEKSSRKNVIQITTPTGHE-----FLLQADHFPTISKWHDAI 171

  Fly   139 NTSIDVCSSNSSSGGSPAVGRSKSGRDRRNGLECCS--SCSKRWHDLKQRMHTLEQDLLVQTTYS 201
            ..::|:.||.|   |..:.||  :...|.|..||.|  :|.......|:......:.::.:..||
Zfish   172 KKAVDILSSGS---GGQSCGR--AALHRSNSTECLSRPTCESSKPKPKETKSEHRRSIMFKLNYS 231

  Fly   202 QELEQKVGEMSRQLTELLQERDRERDKDKARFAAAGGVAAPGKRTAHGSPNVRPSRLVAWMNLSN 266
                                                   |......:|..|          .|..
Zfish   232 ---------------------------------------ASDSADKNGVKN----------RLKK 247

  Fly   267 WFKSRPSVETLREQRIFFDEPCFDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTQPIEGIY 331
            :...|||::||:|:.|..|. .|...: :.|...:..|||:.|..|.:.:|::...:    :|||
Zfish   248 FISRRPSMKTLQEKGIIKDR-VFGCHM-LTLCDREKTTVPKFVKLCVEEVEKRGLEA----DGIY 306

  Fly   332 RQCGDYNKIQTLRFSIDANDYDSLRQPD-VDIHTLTGVLKLFLREIKSPLVRVNEAKTF-----I 390
            |..|:...||.|||.:|..:...|.... .|||.:||.||:|.||:..||........|     |
Zfish   307 RVSGNLAIIQKLRFLVDQEEELDLGDSQWEDIHVITGALKMFFRELPEPLFPFRFFDLFVETIKI 371

  Fly   391 GQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRI-TKVPLQQISAETLSISVTPSI 454
            .:|.|        |:.::|:||..||:.|.:||..:|.|..|: ||.....:|.:.:||...|::
Zfish   372 KEPTQ--------KVQAMKKLIHQLPKPNHNTMKLLFHHLRRVLTKSQKNLMSTQGVSIVFGPTL 428

  Fly   455 FHTVPQGVHMQDIQQLLREGETLADCVKLMIEYQGRIFDRLRLIQTAHLLCRCVERFANHSK 516
            .....:..:|:                 :.:.||.:|.:        .:|..|||.|....|
Zfish   429 MWPEFESGNME-----------------VNMVYQNQIVE--------CILIGCVEIFGPADK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP16F	NP_001285400.1	RhoGAP	306..487	CDD:238090	51/187 (27%)
arhgap15	NP_001122027.1	PH	67..175	CDD:278594	18/116 (16%)
		PH_ARHGAP9-like	68..176	CDD:270053	18/116 (16%)
		RhoGAP_ARHGAP27_15_12_9	269..453	CDD:239868	58/221 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.100