DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scu and FOX2

DIOPT Version :9

Sequence 1:	NP_523396.1	Gene:	scu / 32789	FlyBaseID:	FBgn0021765	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_012934.1	Gene:	FOX2 / 853878	SGDID:	S000001717	Length:	900	Species:	Saccharomyces cerevisiae

Alignment Length:	261	Identity:	77/261 - (29%)
Similarity:	123/261 - (47%)	Gaps:	44/261 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NAVSLVTGGASGLGRATAERLAKQGASVILADL--PSSKGNEVAKELGDKVVFVP--VDVTSEKD 64
            |.|.:|||...|||::.|...|:.||.|::.|:  |.|...|:.|..|:... :|  .||.:|..
Yeast   322 NKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTA-IPDSHDVVTEAP 385

  Fly    65 VSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFNVIRLSAGL 129
            :  .:|||..||.|:|:.||.||.... |:|...|:     |::..|:.::...||:       |
Yeast   386 L--IIQTAISKFQRVDILVNNAGILRD-KSFLKMKD-----EEWFAVLKVHLFSTFS-------L 435

  Fly   130 MGANEPNQDGQR-GVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPG 193
            ..|..|....|: |.|:||.|.:...|..|||.|:|:|||::|.:..||.:.:.:||.:..|||
Yeast   436 SKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAP- 499

  Fly   194 LFNTPMLAALPEKVRTFLAKSIPFPQRLG---EPSEYAHLVQAI-------YENPLLNGEVIRID 248
                        ...|.:.|:|...:.|.   :.|:.:.||..:       |....:.|::..:.
Yeast   500 ------------HAETAMTKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSGRRVIGQLFEVG 552

  Fly   249 G 249
            |
Yeast   553 G 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scu	NP_523396.1	HSD10-like_SDR_c	3..255	CDD:187629	77/261 (30%)
FOX2	NP_012934.1	hydroxyacyl-CoA-like_DH_SDR_c-like	5..255	CDD:187611
		NADB_Rossmann	336..566	CDD:419666	69/247 (28%)
		PLN02864	613..886	CDD:178455
		HDE_HSD	782..894	CDD:239532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910