DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scu and HSD17B1

DIOPT Version :9

Sequence 1:	NP_523396.1	Gene:	scu / 32789	FlyBaseID:	FBgn0021765	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001317148.1	Gene:	HSD17B1 / 3292	HGNCID:	5210	Length:	329	Species:	Homo sapiens

Alignment Length:	258	Identity:	66/258 - (25%)
Similarity:	102/258 - (39%)	Gaps:	50/258 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VSLVTGGASGLGRATAERLAKQGAS-----VILADLPSSKGN--EVAKELG---DKVVFVPVDVT 60
            |.|:||.:||:|...|.|||...:.     ..|.|| .::|.  |.|:.|.   ..:..:.:||.
Human     5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDL-KTQGRLWEAARALACPPGSLETLQLDVR 68

  Fly    61 SEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFNVIRL 125
            ..|.|:||.:...:  ||:|:.|..||...........::..      ..|:::|.|||..:::
Human    69 DSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAV------ASVLDVNVVGTVRMLQ- 124

  Fly   126 SAGLMGANEPNQDGQ-RGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIR-IC 188
                  |..|:...: .|.::.|.||....|......|.|||.|:.|:...:|..|...|:. :.
Human   125 ------AFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLS 183

  Fly   189 TIAPGLFNTPMLAALPEKVRTFLAKSIPFPQRLGEPSEY-----AHLVQAIYENPLLNGEVIR 246
            .|..|    |:..|..|||             ||.|.|.     .|.....|:....:.:|.|
Human   184 LIECG----PVHTAFMEKV-------------LGSPEEVLDRTDIHTFHRFYQYLAHSKQVFR 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scu	NP_523396.1	HSD10-like_SDR_c	3..255	CDD:187629	66/258 (26%)
HSD17B1	NP_001317148.1	NADB_Rossmann	4..262	CDD:304358	66/258 (26%)
		adh_short	5..198	CDD:278532	56/212 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..329
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910