DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7206 and Smg6

DIOPT Version :9

Sequence 1:	NP_996499.1	Gene:	CG7206 / 32788	FlyBaseID:	FBgn0030892	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001002764.1	Gene:	Smg6 / 103677	MGIID:	2144117	Length:	1418	Species:	Mus musculus

Alignment Length:	402	Identity:	84/402 - (20%)
Similarity:	147/402 - (36%)	Gaps:	140/402 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PQRLLKFPPKVAMNAWEKPKALVD-ANRLKAGRTQTAYQRLMLLRASLQQKQLYEERNNNIVAKI 149
            |...|..|.:||::.|   ..|.| .|.|.|              .:..:..||::.::::...|
Mouse  1042 PPTSLDLPLQVAVDVW---STLADFCNILTA--------------VNQSEVPLYKDPDDDLTLLI 1089

  Fly   150 NEE---------VIEKQPEACNITNPSAFDGSTASDM---------------EVEPM-------- 182
            .||         ::....:.|.:...|  |...|:|.               :.||:
Mouse  1090 LEEDRLLSGFVPLLAAPQDPCYVEKTS--DKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKY 1152

  Fly   183 ------------------------EWQESIEEEAAQNDQDEAKKGDDTLLMLPAE------SIEE 217
                                    |.::.:.|:..::.:.|...|:|.:..|.|:      .|.|
Mouse  1153 VSVAPVPDTMGKEMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAE 1217

  Fly   218 EAPQKGQDEAKEEDDTILMLQAADAEELPPRLEDYMYFVLDTNVLIHNHKFVERLTDVVLPGTVG 282
            :..::.:.:|..||.:  .::..:.|..|      ::.|.|||..|.:...:.||.:     :..
Mouse  1218 QQRRQEKIQAVLEDQS--QMRQMELEIRP------LFLVPDTNGFIDHLASLARLLE-----SRK 1269

  Fly   283 SMLYLPYIVIKELDKLKSKYQSD----CLQRVI---AMRAIRFLNTKFD---------------- 324
            .:|.:|.|||.|||.|....::|    ...||:   |.::|.||..:|:
Mouse  1270 YILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNEL 1334

  Fly   325 ESFQIQAQSALEEADHLIKIDCPDDSILNCCL-----QLQAQVP-----------HMILLTNDAN 373
            ||.      |....|...::...||.||:|||     :.:..:|           .::|||:|.|
Mouse  1335 ESI------AFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRN 1393

  Fly   374 LRLKANASNIQV 385
            ||:||...|:.|
Mouse  1394 LRVKALTRNVPV 1405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7206	NP_996499.1	PIN_Smg5-Smg6-like	254..392	CDD:189050	47/171 (27%)
Smg6	NP_001002764.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..86
		EJC-binding motif 1, mediates interaction with the EJC. /evidence=ECO:0000250	39..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..123
		EJC-binding motif 2, mediates interaction with the EJC. /evidence=ECO:0000250	132..152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..402
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..468
		DUF3824	<479..552	CDD:289625
		EST1	637..740	CDD:287360
		EST1_DNA_bind	750..1102	CDD:287359	16/76 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..840
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..882
		PIN_Smg6	1240..1415	CDD:189055	49/183 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1427
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030