DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ada3 and Tada3

DIOPT Version :9

Sequence 1:	NP_001259667.1	Gene:	Ada3 / 32787	FlyBaseID:	FBgn0030891	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_006237102.1	Gene:	Tada3 / 362414	RGDID:	1564009	Length:	440	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	140/503 - (27%)
Similarity:	229/503 - (45%)	Gaps:	127/503 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DVPKLLPTIAAALQRPADDHLAAEDLDAVQLELEQMLSNVALRTRVLKAEYDSL-DKDEKRQDRR 134
            |..|:.|...|.|.|..||.:..|:||.:|||||.:||:.:.|.|||:||...| |..:|:.|||
  Rat    26 DHMKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRR 90

  Fly   135 KL----DRVPGSPPCPASMLNGLLGIGSNSSTSLGSPLGGGGASSSSQSKRKRDEPTGVRKKHSS 195
            .|    |...|:||                  ..|.|           .|:|.:..||
  Rat    91 ILKLARDHELGAPP------------------KHGKP-----------KKQKLEGKTG------- 119

  Fly   196 MTILKQQGVSGGTSKHQAKN-SPLVVH---TDDSMDYLPTLAAANASGSVLPHHQPLPQLPKMTV 256
                  .|...|..:.::|| .|.:..   |||.:|                       :|:  :
  Rat   120 ------HGPGPGPGRPKSKNVQPKIQEYEFTDDPID-----------------------VPR--I 153

  Fly   257 PKNDTPNKFWLSVEPYCMPLTNEDLRLIDDLLEQYWGPLVPP--------VPPLGPHYSTVWAQE 313
            ||||.||:||.||||||..:|:|::|.:::||:       ||        :||||.|||..||||
  Rat   154 PKNDAPNRFWASVEPYCADITSEEVRTLEELLK-------PPEDEAEHYKIPPLGKHYSQRWAQE 211

  Fly   314 DIKALQPGGAR-----------------IKSNNSSGMLKKAEGM----VDESITGPLTQRLVSAL 357
            |:...|..|||                 :.:.:...:|||:|..    .|....|.|||||:.||
  Rat   212 DLLEEQKDGARAAAVADKKKGLIGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQAL 276

  Fly   358 MEESLMTLPSEQAAVGEHSNSTTSSSNENTHSHSSSSANAAAAAASGNFRSLAMMKHGVGIEQRL 422
            :||:::: |.|.:.:.:.|...:.:...:|...:.:...:              :.|...:|.|:
  Rat   277 VEENIIS-PMEDSPIPDMSGKESGADGASTSPRNQNKPFS--------------VPHTKSLESRI 326

  Fly   423 KKTLIENGLIDASEFAAHEDVDEVLMEIKRVTTEISTISQFNSEELKRLRAVASEEIKRIAIKQK 487
            |:.||..||:::.:..|.:..||||.|:::...|:..:|..|..:...|..:|.||:.|..::|:
  Rat   327 KEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQR 391

  Fly   488 LDMVDQEILECYKRMLQYRAKRKGHTIEEKQEILRLTNEQRLLADQLE 535
            :.|.|.|:::.:::::..|.|::..|.:||.:..:...|:..:...|:
  Rat   392 VRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLD 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada3	NP_001259667.1	Ada3	413..518	CDD:287205	30/104 (29%)
Tada3	XP_006237102.1	Ada3	317..430	CDD:402001	31/112 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354017
Domainoid	1	1.000	121	1.000	Domainoid score	I5586
eggNOG	1	0.900	-	-		E1_KOG4191
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4633
Inparanoid	1	1.050	176	1.000	Inparanoid score	I3949
OMA	1	1.010	-	-		QHG48706
OrthoDB	1	1.010	-	-		D1026409at2759
OrthoFinder	1	1.000	-	-		FOG0006498
OrthoInspector	1	1.000	-	-		oto95711
orthoMCL	1	0.900	-	-		OOG6_104616
Panther	1	1.100	-	-	LDO	PTHR13556
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6237
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770