DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ada3 and ngg1

DIOPT Version :9

Sequence 1:	NP_001259667.1	Gene:	Ada3 / 32787	FlyBaseID:	FBgn0030891	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_595671.1	Gene:	ngg1 / 2540436	PomBaseID:	SPBC28F2.10c	Length:	551	Species:	Schizosaccharomyces pombe

Alignment Length:	602	Identity:	114/602 - (18%)
Similarity:	224/602 - (37%)	Gaps:	180/602 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TFLDSEVLATPGGVVIPIIRTR-----DVPKLLPTIAAALQ------RPADDHLAAEDLDAVQLE 102
            ||......:|||  |:|.:.|.     ::.|::....:.::      ...:.|:.:|      :|
pombe    28 TFSRLSETSTPG--VVPSVSTLWRLLFELQKMIECEPSCVEYFRQRKEELESHVDSE------IE 84

  Fly   103 LEQMLSNV-ALRTRVLKAEYDSLDKDEKRQDRRKLDRVPGSPPCPASMLNGL-----LGIGSNSS 161
            ..:..|:| .:..:|.:.:.|:::::.|:  :|.|...|     ..|||..:     :....|..
pombe    85 TSKDESSVNKVEEKVEEFKEDNVEQEIKQ--KRSLSESP-----QESMLEKVSKKPKVSEAHNEE 142

  Fly   162 TS----------LGSPLGGGGASSSSQSKRKRDEPTGVRKKHSSMTILKQQGVSGGTSKHQAKNS 216
            .|          |..|:.|           |.::.||:..|:::..:               ..|
pombe   143 ISPENVETIENELDLPVKG-----------KDEQTTGLVYKNANDLL---------------TGS 181

  Fly   217 PLVVHTDDSMDY-----------LPT-----LAAANASGSVLPHHQPLPQLPKMTVPKNDTPNKF 265
            .|....|||..|           .||     |.|...:.....|::|..|:...|         |
pombe   182 LLSFIVDDSFSYEQKKKLLCVDSFPTSDVRSLVAGTPATDDFSHNKPNNQISIST---------F 237

  Fly   266 WLSVEPYCMPLTNEDLRLID---DLLEQYWGPLVPPVPPLGPHYSTVWAQEDIKALQPG----GA 323
            :.|::||.....::|:..:.   |:...|      .:||||..|..:..::::..|...    ..
pombe   238 YSSLDPYFRAFNDDDIAFLKKGFDVSSSY------NIPPLGERYYDLTPEDEMTNLCANSIYQNL 296

  Fly   324 RIKSNNSSGMLKKAEGMVDESITGPLTQRLVSALM-------EESLMTLP----------SEQAA 371
            :..:..|.....:|:.:.:|...||||:||:::|:       ||...::.          ||::.
pombe   297 QTSAQGSLEAFNEADTVSEEVRCGPLTERLMASLIPCYTQNDEEQKPSIAVGEFAETDSGSEKSK 361

  Fly   372 VGEHSNSTTSSSNENTHSHSSSSANAAAAAASGNFRSLAMMKHGVGIEQRLKKTLIENGLI-DAS 435
            :|...:...|.:||.|.......::.:..                  |.||:.||.:.|:: |..
pombe   362 IGTSIDGIESGNNEYTEQPDIQESSLSIC------------------EDRLRYTLKQLGILYDGD 408

  Fly   436 -EFAAHEDVDEVLMEIKRVTTEISTISQFNSEELKRLRAVASEEIKRIAIKQKLDMVDQEILECY 499
             :::..:| ||:...::.:...:..:|..|.:....|..:..||:.....:..:|.:|::|.:.|
pombe   409 VDWSKRQD-DEISATLRSLNARLKVVSDENEKMRNALLQMLPEEMAFQEFQNVMDDLDKQIEQAY 472

  Fly   500 -KRMLQYRAKRKGHTIEEKQEILRLTNEQRLLADQLERMQMHLPCIGGSGNS----LLEPKMXDR 559
             ||....:.|:|                 |::.|:          ||.|..|    :::..|..|
pombe   473 VKRNRSLKVKKK-----------------RIVTDK----------IGSSATSGSFPVIKSLMDKR 510

  Fly   560 SLAWGWCQ-LMAMHQAK 575
            |:   |.: |..:.|.|
pombe   511 SM---WLEKLQPLFQDK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada3	NP_001259667.1	Ada3	413..518	CDD:287205	23/107 (21%)
ngg1	NP_595671.1	Ada3	390..508	CDD:287205	29/163 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006498
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104616
Panther	1	1.100	-	-	LDO	PTHR13556
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R809
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840